Joint Health - There are 14 different types of collagen found in the body but only type II is the most abundant in the joint matrix. CellRenew and its components can have a powerful impact on joints and conditions associated with abnormal joint function. One study¹⁹ published in 2000 entitled "Role of collagen hydrolysate in bone and joint disease", reviews how collagen can be a powerful tool in helping with osteoarthritis and even osteoporosis. The researchers of this study state "Its high level of safety (hydrolyzed collagen) makes it attractive as an agent for long-term use in these chronic disorders."

Mechanism of action: The components of CellRenew including chondroitin sulfate, Hyaluronic Acid, and glucosamine sulfate can support proteoglycans and glycosaminoglycans (GAG's) in the joint matrix thereby increasing synovial (joint) fluid and supporting cartilage synthesis in the joints. This can enhance a joint's shock absorption capabilities as well as lower the chance for deterioration.

Hyaluronic Acid specifically is a key nutrient in joint health. In a review by Moskowitz¹⁵ from Case Western Reserve University entitled "Hyaluronic acid supplementation" and published in 2000, he states that "Hyaluronan preparations have been shown to decrease pain and increase function in patients with osteoarthritis of the knee."

Mechanism of action: Hyaluronic Acid seems to work through several mechanisms of action including restoration of more normal synovial fluid with improved viscoelasticity, effects on cartilage biosynthesis and degradation, anti-inflammatory effects, and direct analgesic effects.¹⁸

Skin Health - Collagen is one of the most important substances required for the proper functioning of skin. It provides structural support to the skin thereby increasing elasticity and skin tone. Hyaluronic acid is also present in skin tissue including both the dermis (interior) and epidermis (exterior). It supports healthy skin function. In one study published in the Journal of Cellular Physiology in 1998, Hyaluronic Acid was shown to help proliferate healthy skin cells in a collagen matrix.¹⁷

Mechanism of action: Hyaluronic Acid enhances skin moisture (hydration) and functions as a lubricant between the collagen matrix of the skin. Since it is a component of the skin structure and declines with age, supplementation can insure adequate levels remain in the skin to support its healthy appearance and function.

Wound Healing - Hyaluronic acid has been shown to support wound healing, mainly as a topical application. In a study entitled "The properties of hyaluronan and its role in wound healing" published in 2001, Hyaluronic Acid is discussed as having wound healing properties. It seems to work through its water retaining properties.¹⁶