Biotin is one of the vitamin B-Complex vitamins. It is a cofactor for many enzymatic reactions occurring in mammalian cells. Biotin is needed for growth, maintenance of skin, nerves, sex glands, bone marrow, and sebaceous glands.
Until recently, biotin was not recognized as being clinically significant because it was believed that the gastrointestinal bacteria produced a sufficient amount of biotin for the body's needs. In the early 1970's however, an inborn error of biotin metabolism was reported and, shortly thereafter, other biotin deficient individuals were recognized.
Biotin is stable when food is heated, stored, or processed.
Method of Action
Biotin is involved with the metabolism of fatty acids, amino acids, and carbohydrates. It is used as a coenzyme for the removal of carbon dioxide from oxaloacetate, succinate, malate, and aspartate; it is also used in the biosynthesis of citrulline, aspartate, and unsaturated fatty acids, and in other reactions involving the transfer of carbon dioxide.
Biotin in enzymes is usually connected to a lysine residue. There are nine known enzymes which require biotin to function, but only four of the nine exist in mammalian cells; the other enzymes are found in microorganisms.
Properties & Uses
Biotin has been used successfully to treat seborrheic dermatitis in infants in the United States and Europe. Inconclusive results have been achieved in the treatment of other skin and scalp disorders, such as baldness.
Consequence of Deficiency
Biotin deficiencies are not frequently found in humans. The small amount of biotin required is usually supplied by the diet and by microorganisms in the gastrointestinal tract.
One possible cause of biotin deficiency is the eating of raw egg white. Raw egg white contains avidin which complexes to biotin and prevents its absorption into the body. Other causes of biotin deficiency include other antagonists to biotin as well as inborn metabolic errors.
The symptoms of biotin deficiency are: dermatitis, nausea, depression, vomiting, and anorexia. These symptoms occur only under highly abnormal, or experimental, conditions.
Biotin is essentially nontoxic to humans.
Recommended Dietary Allowance
RDA for adults: 150 - 300 mcg RDA for children: Unknown
The above is 1980 values for RDA.
Biotin is taken orally for biotin deficiency.
For over thirty years, Recommended Daily Amounts has existed in the United Kingdom. It has been used to measure the adequacy of an individual's diet. However, in 1991 the Committee on Medical Aspects of Food Policy (COMA) gave forth a whole new set of figures upon the request of the Department of Health's Chief Medical Officer. Reference Nutrient Intake (RNI) is one of these sets collectively known as "Dietary Reference Values." RNI is an amount of a nutrient that is enough for almost every individuals, even someone who has high needs for the nutrient. This level of intake is, therefore, considerably higher than what most people would need. If individuals are consuming the RNI of a nutrient they are most unlikely to be deficient in that nutrient.
The United Kingdom RNI in the COMA 1991 repor suggests that intakes between 10 and 200mcg are both safe and adequate.
Lamb liver Pork liver Royal jelly Yeast
Almonds Barley Beef liver Cauliflower Chicken Chocolate Corn Cowpeas Eggs Garbanzos Hazelnuts Lentils Mackerel Mushrooms Oat flakes Peanuts Pecans Rice Salmon Sardines Soybeans Walnuts Wheat
Apples Avocados Bananas Cantaloupe Cheese Grapefruit Grapes Milk Oranges Peaches Strawberries Watermelon
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