Pantothenic acid (vitamin B-5) is a heat-labile, water-soluble vitamin vital to all the energy requiring processes of the body because it is the precursor of coenzyme A (CoA).
Because it is heat-labile, it is readily destroyed by cooking with dry heat, such as occurs in canning. Canning destroys 20-35% of the vitamin in animal sources, and 46-78% of the vitamin found in plant foods. Grain loses 50% of its pantothenic acid content during milling.
Pantothenic acid is found in all naturally-occurring foods.
Method of Action
Pantothenic acid is a simple chemical which contains alanine. In the body, it couples with a sulfur-containing compound to form pantothenine. The addition of a phosphate group and an adenine molecule results in the formation of coenzyme A (CoA).
Pantothenic acid, by virtue of being the precursor of CoA, is directly involved in the metabolism of carbohydrates, proteins, and lipids, and plays a role in all the energy-requiring processes of the body.
Pantothenic acid makes possible the biosynthesis of fatty acids, phospholipids, cholesterol, and steroid hormones. A deficiency may cause adrenal cortex insufficiency or even necrosis.
Pantothenic acid, through CoA, fuels the metabolism of porphyrin and therefore controls the formation of hemoglobin.
Pantothenic acid is responsible for the production of isoprene units, the basic building blocks of fat-soluble vitamins.
The synthesis of niacin from its precursor tryptophan is facilitated by pantothenic acid in conjunction with biotin.
Properties & Uses
Pantothenic acid reverses the graying of hair in rats and dogs. It does not, however, correct graying in human beings.
Pantothenic acid can be administered after surgery to correct residual paralysis of the gastrointestinal tract. This treatment is effective because the vitamin appears to stimulate gastric motility. The patient must be carefully monitored because high levels (10 to 20 grams) cause diarrhea.
Consequence of Deficiency
The following symptoms have been associated with Pantothenic acid deficiency in animal models:
Dermatitis - chick
Graying of the hair - rat
Adrenal gland necrosis - rat
Bloody whiskers - rat
Baldness - mice
There have been no reports of spontaneous, uncomplicated deficiency diseases for humans. This is not surprising given its widespread availability in naturally-occurring foods, and possible synthesis by intestinal bacteria.
Experimental deficiencies have been produced in humans. The following symptoms were exhibited by various subjects:
Tingling of the hands and feet
Increased susceptibility to infection
Pantothenic acid is thought to be nontoxic because excessive dosages produce no known serious effects. This vitamin does, however, stimulate gastric hypermotility at dosages of 10 to 20 grams, producing diarrhea.
Recommended Dietary Allowance
Lactating and pregnant women may require more than the standard 4 to 7 milligrams of pantothenic acid per day.
For over thirty years, Recommended Daily Amounts has existed in the United Kingdom. It has been used to measure the adequacy of an individual's diet. However, in 1991 the Committee on Medical Aspects of Food Policy (COMA) gave forth a whole new set of figures upon the request of the Department of Health's Chief Medical Officer. Reference Nutrient Intake (RNI) is one of these sets collectively known as "Dietary Reference Values." RNI is an amount of a nutrient that is enough for almost every individuals, even someone who has high needs for the nutrient. This level of intake is, therefore, considerably higher than what most people would need. If individuals are consuming the RNI of a nutrient they are most unlikely to be deficient in that nutrient.
There is no specific recommendation by COMA 1991. An adequate intake of Pantothenic Acid is thought to be 3 - 7 mg a day. An adequate content for infants formula is approximately 2 mg per liter (1.75 mg per day).
Pantothenic acid is found in all naturally-occurring foods.
High: (2.0 - 10.0 mg/100 g)
Beef brain Egg yolk Beef heart Lamb kidney Beef liver Lamb liver Beef kidney Liverwurst Bran flake Peanuts Brewer's yeast Pork kidney Chicken liver Pork liver Green peas (dried) Royal jelly Wheat germ
Medium: (0.5 - 2.0 mg/100 g)
Avocado Kale Bacon Lentil Beef Lima beans Broccoli Mackerel Carrots Mushrooms Cauliflower Oat flakes Cheese Rice Chicken Salmon Clams Soybeans Egg Spinach Green peas Walnuts Ham
Low: (0.1 - 0.5 mg/100 g)
Almonds Oatmeal Apples Onion Bananas Orange juice Cabbage Oranges Grapefruit Oysters Grapes Peaches Honey Pears Kidney beans Pineapples Lemons Plums Lettuce Sweet potatoes Lobster Shrimp Milk Tomatoes Molasses Veal
Bassler, K.H. & Lang K. ;Vitamine 2. Aufl. (Steinkopff, Darmstadt) p.68, 1981.
Eagles, J.A. & M.N. Randall. 1980. Handbook of Normal and Therapeutic Nutrition. Raven Press, New York. 323.
Eschleman, M.M. 1984. Introductory Nutrition and Diet Therapy. J.B. Lipincott Co., Philadelphia. 464.
Goodhart, Robert S. & Maurice E. Shills. Modern Nutrition In Health And Disease. 6th edition. Philadelphia: Lea and Febiger, 1973.
Guthrie, Helen A. Introductory Nutrition. 5th edition. St. Louis: C.V. Mosby Co., 1971.
Harper, H.A., Rodwell, V.A, Mayes P.A.; Review of physiological Chemistry, Los Altos, CA. Lang Medical Publications, Ch 13, 1979.
Howe, P.S. 1981. Basic Nutrition in Health and Disease, 7th ed. W.B. Saunders Co., Philadelphia.
Kirschmann, J.D. Nutrition Almanac: Nutrition Search. McGrew-Hill: New York. 1990.
Krause, M.V. & L.K. Mahan. 1979. Food, Nutrition and Diet Therapy. 6th ed. W.B. Saunders Company, Philadelphia. 963.
Kutsky, R.J. 1973. Handbook of Vitamins and Hormones. Van Nostrand Reinhold, Co. New York, New York. 278.
Lehninger, A.L. Principles of Biochemistry. Worth Publi, Inc, N Y. 1011.
Leung-LH: Pantothenic acid deficiency as the pathogenesis of acne vulgaris. Med-Hypotheses. 1995 Jun; 44(6): 490-2.
Linder, M.C. Ph.D. ed.: Nutritional Biochemistry and Metabolism With Clinical Applications. 2nd. ed. Elsevier, New York. p. 120, 1991.
Moran J. R. & Green H. L.; Amer. J. Dos. Child 133:308, 1979.
Mose-S et al: Efficacy of prophylactic application of immunoglobulins in radiation induced mucositis. Strahlenther-Onkol. 1995 Jul; 171(7): 415-6.
Murray, M.T. & Pizzorno, J.E. Encyclopedia of Natural Medicine. Rocklin, CA: Prima Publishing,1991.
Osol, Arthur. 1980. Remington's Pharmaceutical Sciences. Mack Publishing Company, Pennsylvania. 1928.
Recommended Dietary Allowances. 1989. National Academy of Science, National Academy Press, Washington, D.C.
Recommended Dietary Allowances, 9th ed.; Committee on Dietary Allowances and Food and Nutrition Board, National Research Council, National Academy of Science, Washington, DC, 1980.
Savin-AA et al: [Russian preparations for the metabolic therapy of multiple sclerosis patients]. Zh-Nevropatol-Psikhiatr-Im-S-S-Korsakova. 1995; 95(2): 37-40.
Shibata, K., Gross C.J. & Henderson L.M.; J. Nutrition, 113:2107, 1983
Walji, H., Vitamin Guide: Essential nutrients for healthy living., Element: Dorset, U.K. 1992.
Walji, H., Vitamin Minerals & Dietary Supplements., Hodder Headline Plc.: London, U.K. 1994.
Whitney, E.N. and C.B. Cataldo. 1983. Understanding Normal and Clinical Nutrition. West Publishing Company. St. Paul, Min. 1230.