Rutin Supplements

Description

Rutin, a bioflavonoid, is a crystalline glucoside of quercetin, closely related to hesperidin. It is principally derived from buckwheat but is present in many other plants, including eucalyptus leaves, hawthorn, rose hips, rue and blue violet leaves.

Method of Action

Rutin acts as an antioxidant.

Therapeutic Approaches

Rutin is being tried as a free radical scavenger, with the potential to be cytoprotective and possibly anti-inflammatory.

A combination bioflavonoid will generally contain 500 mg of which 85 mg may be Rutin.

Toxicity Factors

Rutin, like other bioflavonoids, has a low toxicity and is generally recognized as safe.

Abstracts

References

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Carlotti-ME; Gallarate-M; Gasco-MR; Trotta-M. Inhibition of lipoperoxidation of linoleic acid by five antioxidants of different lipophilicity. Pharmazie. 1994 Jan; 49(1): 49-52

Elangovan-V; Sekar-N; Govindasamy-S. Chemopreventive potential of dietary bioflavonoids against 20-methylcholanthrene-induced tumorigenesis. Cancer-Lett. 1994 Nov 25; 87(1): 107-13

Grinberg-LN; Rachmilewitz-EA; Newmark-H. Protective effects of rutin against hemoglobin oxidation. Biochem-Pharmacol. 1994 Aug 17; 48(4): 643-9

Hanasaki-Y; Ogawa-S; Fukui-S. The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free-Radic-Biol-Med. 1994 Jun; 16(6): 845-50

Hendrickson-HP; Kaufman-AD; Lunte-CE. Electrochemistry of catechol-containing flavonoids. J-Pharm-Biomed-Anal. 1994 Mar; 12(3): 325-34

Kootstra-A. Protection from UV-B-induced DNA damage by flavonoids. Plant-Mol-Biol. 1994 Oct; 26(2): 771-4

Larocca-LM; Giustacchini-M; Maggiano-N; Ranelletti-FO; Piantelli-M; Alcini-E; Capelli-A. Growth-inhibitory effect of quercetin and presence of type II estrogen binding sites in primary human transitional cell carcinomas. J-Urol. 1994 Sep; 152(3): 1029-33

Mahady-GB; Beecher-CW. Quercetin-induced benzophenanthridine alkaloid production in suspension cell cultures of Sanguinaria canadensis. Planta-Med. 1994 Dec; 60(6): 553-7

Oyama-Y; Fuchs-PA; Katayama-N; Noda-K. Myricetin and quercetin, the flavonoid constituents of Ginkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca(2+)-loaded brain neurons. Brain-Res. 1994 Jan 28; 635(1-2): 125-9

Peaston, M.J.T. & P. Finnegan. 1968. A case of combined poisoning with chlorpropamide, acetylsalicylic acid and paracetamol. British Journal of Clinical Practice. 22.

Perez-Guerrero-C; Martin-MJ; Marhuenda-E. Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins. Gen-Pharmacol. 1994 May; 25(3): 575-80

Ramanathan-R; Das-NP; Tan-CH. Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. Free-Radic-Biol-Med. 1994 Jan; 16(1): 43-8

Scambia-G; Ranelletti-FO; Panici-PB; De-Vincenzo-R; Bonanno-G; Ferrandina-G; Piantelli-M; Bussa-S; Rumi-C; Cianfriglia-M; et-al. Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer-Chemother-Pharmacol. 1994; 34(6): 459-64

Thomas, C.L. 1985. Taber's Cyclopedic Medical Dictionary. F.A. Davis Co. Pub. Philadelphia. 2170.

Tezabwala-BU et al: Immunotoxicity of polyunsaturated fatty acids in serum-free medium. Immunopharmacol-Immunotoxicol. 1995 May; 17(2): 365-83.

Weiner, Michael & A. Janet Weiner. 1980. Weiner's Herbal The Guide to Herb Medicine. Stein and Day. New York. 224.