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Generic and Trade Names

Acetazolamide                        (Diamox)


Acetazolamide is a prescription drug used to treat glaucoma (see under glaucoma), and it has diuretic properties as well. It is used in the treatment of edema, epileptic seizures, and problems caused by high altitude such as fatigue, shortness of breath, and insomnia. Severe kidney, pulmonary or liver disease is a contraindication for using this drug. (Facts and Comparisons 1999)

Nutritional Considerations:

Electrolytes should be maintained and potassium supplementation may be needed. (Facts and Comparisons 1999) (Pronsky 1999)

Insure adequate fluids unless otherwise directed by a physician. (Pronsky 1999)

Herbal Considerations:

Avoid natural licorice products. (Pronsky 1999)

Natural sources of salicylates may evoke salicylate toxicity, which include: vomiting, tachycardia and hyperpnea. Acetazolamide toxicity can include: lethargy and somnolence. (Sweeney 1986)

Celery seed may theoretically interact with acetazolamide due to its diuretic properties. (Newall 1996)


Angel, J.E. 1983. Physicians Desk Reference. Medical Economics Company, Inc. Oradell, New Jersey.

Bietti G, Virno M & Picori-Giraldi J: Acetazolamide, metabolic acidosis, and intraocular pressure. Am J Ophthalmol 1975; 80:360.

Critchlow AS & Freeborn SF: Potassium supplements during treatment of glaucoma with acetazolamide. Br Med J 1984; 289:21.

Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 1999.

Kurz M: Diamox und manifestierung von diabetes mellitus. Wien Med Wochenschr 1968; 118:239.

McMurdo MET, Hutchison GL & Lindsay G: Taste disturbance with acetazolamide (letter). Lancet 1990; 336:1190-1191.

Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996

Pronsky, Zaneta. Food Medication Interactions. 11th edition. 1999.

Shelley WB: Birch pollen and aspirin psoriasis. JAMA 1964; 189:985-988.

Sweeney KR, Chapron DJ, Brandt JL et al: Toxic interaction between acetazolamide and salicylate: case reports and a pharmacokinetic explanation. Clin Pharmacol Ther 1986; 40:518-524. "