Anorectic (Anorexiant)

Generic and Trade Names:

Benzocaine			Slim-Mint, Trocaine
Benzphetamine HCl			Didrex
Diethylpropion			Tenuate
Mazindol				Sanorex
Phenylpropanolamine HCl		Acutrim
Phendimetrazine tartrate		Adipost
Phentermine HCl			Adipex
Sibutramine			Meridia

Description:

Anorectics (anorexiants, anorexics) form a group of drugs that are indirect acting sympathomimetic amines. They are similar to the amphetamine class, and are referred to as the nonamphetamine anorexiants. They are used to manage exogenous obesity. (See under anorexia and anorexia nervosa.)

The exact mechanism of action is not known, but it is reported anorectics suppress apetite by directly stimulating the hypothalamic and limbic regions which control satiety. Examples include, phenylpropanolamine, and Phentermine hydrochloride. (Facts and Comparisons 1999)

Nutritional Considerations:

Hydration: insure adequate fluid intake unless directed otherwise. (Pronsky 1999)

Do not take at bedtime, take the hydrochloric forms at least 2 hrs after breakfast. Take the resin forms half an hour before breakfast. (Pronsky 1999)

Electrolytes should be maintained. (Pronsky 1999)

Caution with diabetics, may alter insulin effects. (Pronsky 1999)

Avoid alcohol (Pronsky 1999)

Avoid caffeine found in tea and coffee, because it can cause severe hypertension or mania when combined with phenylpropanolamine. (Brinker 1998)

Herbal Considerations:

Phenylpropanolamine can inhibit the clearance or metabolism of Cocoa,
Cola, Guarana,and Mate thereby increasing its effects. (Brinker 1998)

[N.B. The FDA has withdrawn Pondimin (Fenfluramine) and Redux (Dexfenfluramine). However, Fastin (Phentermine) remains on the market to be used by itself.]

References

Brinker,Francis N.D. Herb Contraindications and Drug Interactions. 1998

Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 1999.

Lake, C.R. et al: Phenylpropanolamine and caffeine use among diet center clients. Int. J. Obesity, 1990, 14: 575-582.

Pronsky, Zaneta. Food Medication Interactions. 11th edition. 1999.