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Hydroxychloroquine Sulfate

Hydroxychloroquine Sulfate

Generic and Trade Names:

Hydroxychloroquine SulfatePlaquenil


Hydroxychloroquine sulfate is a prescription drug classified as an antimalarial and antirheumatic agent. It is used to treat malaria, rheumatoid arthritis, discoid and systemic lupus erythematosus.

In the treatment of malaria, hydroxychloroquine sulfate inhibits the malaria organism from replicating. In the treatment of arthritis and lupus erythematosus, it decreases the inflammatory response in the joints. (Facts and Comparisons 1999)

Nutritional Considerations:

Take with food for stomach upset. (Facts 1999)

Use with caution in patients with G6PD deficiency because of an increased risk of hemolytic anemia. (Pronsky 1999)

Diarrhea, abdominal cramps. (Pronsky 1999)

Herbal Considerations:

The known hepatotoxicity associated with herbs like: comfrey, skullcap, valerian, germander, mistletoe, pennyroyal, chaparral, senna fruit extracts and safrole isolated from basil, camphor, cinnamon, and sassafras, may increase the hepatotoxic effects of the antirheumatic agent, hydroxychloroquine sulfate. (Blumenthal 1998)(Newall 1996)


Angel, J.E. 1983. Physicians Desk Reference. Medical Economics Company, Inc. Oradell, New Jersey.

Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.

Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 1999.

Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996

Pronsky, Zaneta Food Medication Interactions, 11th edition, 1999.