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Skeletal Muscle Relaxants

Skeletal Muscle Relaxants


Generic and Trade Names:

BaclofenLioresal
CarisoprodolSoma
Chlorphenesin carbamateMaolate
ChlorzoxazoneParafon Forte, Paraflex
CyclobenzaprineFlexeril
Dantrolene sodiumDantrium
Diazepam Valium
Metaxolone Skelaxin
MethocarbamolRobaxin
Orphenadine citrate Norflex
TizanidineZanaflex



Description:

These agents work in various ways to manage skeletal muscle pain or spasms. They range from working directly at the site of spasms to a general central nervous system depression to relieve pain and relax skeletal muscles. (Facts and Comparisons 1999)

Nutritional Considerations:

Grapefruit juice may interact with diazepam by increasing its duration of effect. (Ozdemir 1998)

Avoid alcohol. (Facts and Comparisons 1999)

Avoid caffeine: in coffee, black and green tea. (Brinker 1998)

Herbal Considerations:

The caffeine in cocoa, cola, guarana, mate, may interact with diazepam to decrease its sedative effects. (Brinker 1998)

Depolarizing muscle relaxants may theoretically interact with cardioactive herbs to increase the risk of arrhythmias. (Newall 1996)

Herb                                
Broom        Alkaloids,                 
Calamus                                
Cereus        Tyramine,         
Cola        Caffeine
Coltsfoot                                
Devil's Claw        
Fenugreek        
Figwort        
Fumitory        
Ginger        


References

Brinker, Francis N.D. Herb Contraindications and Drug Interactions. Eclectic Medical Publications, 1998.

Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 1999.

Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996

Ozdemir M, Aktan Y, Boydag BS. Interaction between grapefruit juice and diazepam in humans. Eur J Drug Metab Pharmacokinet 1998; 23:55-9.

Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999.