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Thiazide Diuretic

Thiazide Diuretic

Generic and Trade Names:

HydrochlorothiazideHydro-Diuril, [HCTZ],
Esidrix, Oretic


Thiazide drugs are used to reduce blood pressure and edema in conditions like: hypertension, renal failure, congestive heart failure, and pulmonary edema. (See also under bloating, PMS, and water retention.)

Thiazide diuretics block sodium and chloride reabsorption in the kidney, thus increasing the amount of filtrate released by the kidney as urine.

Examples of thiazides are: chlorothiazide, hydrochlorothiazide, methyclothiazide, polythiazide and trichlormethiazide .

Hydrochlorothiazide may also be combined with other drugs e.g. amiloride HCL (Moduretic). (Facts and Comparisons 1999)

Nutritional Considerations:

Thiazide diuretics are potassium-depleting (Al Ghamdi, Dai, Dychner, Whang). Hence the use of potassium supplementation, or potassium preserving diuretics is recommended by many physicians.

While potassium is most widely recognized, magnesium, sodium and zinc are also lost and may require supplementation (Roe, Reyes, Cohanim, Mountokalakis,Shils, Whang).

Vitamin D used to treat hypoparathyroidism may interact to cause hypercalcemia with thiazide diuretics. (McKevoy 1998)

Limit alcohol.

Other vitamins requring supplementation may include: vitamin B1, vitamin B6 and riboflavin (B-2). (Pinto 1987)

Herbal Considerations:

Gingko may increase blood pressure if used with thiazide diuretics.(Shaw 1997)

Avoid natural licorice products (they tend to promote fluid retention) (Shintani, Wichtl).

Cascara sagrada, rhubarb plant and senna aggravate potassium loss caused by diuretics. (Blumenthal 1998)

Newall has also compiled an extensive list of herbs which possess diuretic action:

Agrimony, Artichoke, Boldo, Broom, Buchu, Burdock, Celery, Cornsilk, Couchgrass, Dandelion, Elder, Guaiacum, Juniper, Pokeroot, Shepherd's Purse, Squill, Uva Ursi and Yarrow.

The German Commission E has noted an interaction between thiazide diuretics and these herbs:

Buckthorn bark/berry
Cascara sagrada bark
Licorice root
Senna pod and leaf


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