Gossypol is commonly derived from cotton (Gossypium spp.)
It was identified as an infertility agent in China during the 1950s.
It is a potentially toxic phenolic pigment.
US production is 50,000 tons p.a. as a by-product of cottonseed oil production.
Gossypol is nonsteroidal and acts by inhibiting sperm production and motility. It does not affect sex hormone levels or libido.
It targets a specific enzyme (lactate dehydrogenase X).
The usual daily dose is 20 mg for 2 - 3 months with maintenance doses of 75 - 100 mg twice a month. (3 g p.a.)
This effect may be permanent i.e. sterility.
However, it is also effective as a topic spermicide.
It has also shown activity against HIV and herpes viruses.
Facts and Comparisons. The Lawrence Review of Natural Products. Nov, 1994.
Prusoff, W et al., Empirical and rational approaches for development of inhibitors of the human immunodeficiency virus (HIV-1). Pharmacol. Ther. 1993, 60:315-329.
Wichmann, K et al., Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. Am. J. Obstet. Gyn. 1982, 142:593.
Wu: An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynecological disease. Drugs, 1989, 38:333.
- Product Categories
- Detox & Immunity
- Digestive Health
- Joint Health
- Weight Loss
- Popular Products
- CellRenew Collagen Hyaluronic Acid
- Foundation Blue-Green Algae
- Dream Health System
- Liver Cleanse
- Reference Materials
- Product Testimonials
- Health Journal Archive
- Health Briefs
- Health Basics
- Frequent Product Q&A's
- Med-Scope (health database)
- Health Conditions
- Natural Solutions
- Alternative Therapies
- Toxicity Sources
- Foods Advice
- Anatomy & Fitness