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Isovaleric Acid

Isovaleric Acid

Isovaleric acid is a volatile acid found in hops oil, tobacco, and many other plants. Isovaleric acidemia is a symptom of an impaired enzyme, (isovaleryl-CoA dehydrogenase), in which an excessive concentration of isovaleric acid accumulates in the blood and is excreted through the urine and sweat. Some of the symptoms of too much isovaleric acid in the blood are: a cheesy odor of breath, vomiting, and coma. These symptoms occur after ingestion of a large amount of protein. Isovaleric acid is used industrially as a flavoring agent, in perfumes, and in the manufacture of sedatives.


References
Leung, Albert Y. 1980. Encyclopedia of Common Natural Ingredient used in Food, Drugs and Cosmetics. John Wiley and Sons, N Y. 409 pp.

David W. Martin, Peter A. Muyers, et. al. 1983. Harper's Review of Biochemistry. Lange Medical Publications. Los Altos, Ca. 638 pp.

Windholz, Martha, Susan Budavani, et. al. 1976. The Merck Index. Merck and Co., Inc. New Jersey.