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Drug Name: Avandia

Drug ID: 261

Nutritional Considerations

  • Limit or avoid alcohol.

    1. Graedon J, Graedon T: The People's Guide to Deadly Drug Interactions, 1995
    2. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
  • Caution with high doses of nicotinic acid as it raises glucose levels .

    1. Balch, J.F. & Balch, P.A.: Prescription for Nutritional Healing. Second Edition. Avery, New York. 1996.
    2. Schwartz ML. Severe reversible hyperglycemia as a consequence of niacin therapy. Arch Intern Med. 1993 Sep 13;153(17):2050-2.
  • The supplement ipriflavone may increase the blood levels of oral antidiabetic agents. This could cause blood sugar to fall dangerously low. Consult a physician before taking ipriflavone with oral hypoglycemic agents.

    1. Monostory K, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 123(4): 605-610, 1998.
  • These supplements may reduce blood sugar levels and require a dosage adjustment of Avandia: carnitine, chromium, coenzyme Q10 and vanadium.

    1. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Human Hypertens 13: 203-208, 1999.
    2. Mingrone G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Col Nutr 18: 77-82, 1999.
    3. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med 27: 309-314, 1999.
    4. Cohen N, et al. "Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus." J Clin Invest, 1995; 95: 2501-509.
  • Potatoes can interfere with blood sugar levels and Avandia dosage may require adjustment.

    1. Gannon MC, et al. Diabetes Care 1993;16:874.
    2. The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000

Herbal Considerations

  • The bulbs of the common onion plant and common garlic plant, as well as leaves of bilberry and blueberry have significant oral hypoglycemic action. Hypoglycemic medications may require adjustment.

    1. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
    2. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
    3. Mathew PT and Augusti KT. Hypoglycaemic effects of onion, Allium cepa Linn. on diabetes mellitus, a preliminary report. Indian J Physiol Pharmacol 19: 213-217, 1975
  • These herbs may reduce blood sugar levels and therefore require an adjustment in the dosage of Avandia: : bitter melon, burdock, dandelion, fenugreek, ginseng, and gymnema.

    1. Akhtar MS. Trial of Momordica charantia Linn (Karela) powder in patients with maturity-onset diabetes. J Pak Med Assoc 32: 106-107, 1982.
    2. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
    3. Yaniv Z, Dafni A, Friedman J, et al. Plants used for the treatment of diabetes in Israel. J Ethnopharmacol 19(2): 145-151, 1987.
    4. Bever BO and Zahnd GR. Plants with oral hypoglycemic action. Q J Crude Drug Res 17: 139-196, 1979.
    5. Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 17: 277-282, 1986
    6. Boden G, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 45: 1130-1135, 1996

NDC Codes

00029315813, 00029315818, 00029315820, 00029315821, 00029315825, 00029315838, 00029315862, 00029315866, 00029315913, 00029315918, 00029315920, 00029315921, 00029315925, 00029315938, 00029315961, 00029315967, 00029316013, 00029316020, 00029316021, 00029316025, 00029316038, 00029316061, 51129162701, 51129162801