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Chlorzoxazone

Drug Name: Chlorzoxazone

Drug ID: 280

Nutritional Considerations

  • Take with food to reduce gastrointestinal irritation.

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999.
    2. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
  • Avoid alcohol.

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999.
    2. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.

Herbal Considerations

  • Use of this medication with watercress decreases elimination of the drug and thus, may cause an elevation of the drug's effects.

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999.
    2. Leclercq I, Desager JP, Horsmans Y. "Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress". Clin Pharmacol Ther, 1998; 64:144-149.
  • The sedative properties of these herbs may increase CNS side effects of chlorzoxazone : calamus, calendula, california poppy,catnip, couch grass, elecampane, siberian ginseng , chamomile (german), goldenseal, gotu kola, hops, jamaican dogwood, kava, lemon balm, sage, sweet bay, st. john's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian,wild carrot, wild lettuce, withania root, and yerba mansa.

    1. Fetrow CW, Avala JR. Professional's Handbook of Complementary and Alternative Medicines. Springhouse Corporation, 1999.
    2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
    3. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    4. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.

NDC Codes

00093054201, 00093054205, 00182118901, 00182118905, 00555058502, 00555058504, 00555058505, 00555058518, 00677122101, 00904030240, 00904030260, 49884001601, 49884001610, 50111086101, 50111086102, 50111086103, 51079047620, 51129179801, 51655013724, 51655013729, 51655013751, 51655013752, 51655013795, 51660003301, 51660003305, 51660003310, 52152002502, 52152002505, 52152005302, 52152005305, 52544069301, 53489019301, 53489019305, 54569197000, 54569197001, 54569197002, 54569197004, 54569197005, 54569197006