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Drug Name: Climara

Drug ID: 180

Nutritional Considerations

  • Climara may increase risk of folic acid deficiency, which could affect reproductive and cardiovascular health. Supplementation is considered beneficial.

    1. Roe DA. Nutrition and the contraceptive pill. In: Winick M, ed. Nutritional Disorders of American Women. New York: John Wiley and Sons; 1977:37-49.
    2. Lindenbaum J, Whitehead N, Reyner F. Oral contraceptive hormones, folate metabolism, and the cervical epithelium. Am J Clin Nutr 1975;28:346-53.
    3. Kornberg A, Segal R, Theitler J, et al: Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives, Isr J Med Sci, 1989, 25 (3): 142-5.
    4. Harper JM, Levine AJ, Rosenthal DL, et al: Erythrocyte folate levels, oral contraceptive use and abnormal cervical cytology, Acta Cytol, 1994, 38 (3): 324-30.
  • Climara may affect absorption of certain B vitamins, magnesium, and zinc. Supplementation of these nutrients is suggested.

    1. Zava, DT: Estrogen and progestin bioactivity of foods, herbs and spices. Proc. Soc. Exp. Biol. Med. 1998, 217:369-378.
    2. Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973;I:897-904.
    3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998
    4. Blum M, Kitai E, Ariel Y, Et Al: Oral Contraceptive Lowers Serum Magnesium, Harefuah, 1991, 121 (10):363-4.
    5. Seelig Ms, Interrelationship Of Magnesium And Estrogen In Cardiovascular And Bone Disorders, Eclampsia, Migraine, And Premenstrual Syndrome, J Am Coll Nutr, 1993, 12(4):442-58.
    6. Webb JL, Nutritional effects of oral contraceptive use, a review, J Reprod Med, 1980, 25 (4): 150-6.
  • Talk to your doctor about calcium supplementation, exercise, and doing periodic bone density screenings, with long term use of the medication.

    1. Rybacki, JM. The Concise Guide to Prescription Drugs. Harper, 1997.

Herbal Considerations

  • The following herbs may affect hormone levels: Agnus Castus (Vitex), Alfalfa, Bayberry, Black Cohosh, Dong Quai, Ginseng, Horseradish, Kelp, Licorice Root, Motherwort, Pleurisy Root, Red Clover, Red Sage, Saw Palmetto, Vervain, Wild Carrot Seed, and Wild Yam. Consult your pharmacist for more information.

    1. Ferguson T: The Smoker’s Book of Health, G.P. Putnam’s Sons, New York, 1987.
    2. Zava, DT: Estrogen and progestin bioactivity of foods, herbs and spices. Proc. Soc. Exp. Biol. Med. 1998, 217:369-378.
    3. Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000

NDC Codes

00089031024, 00089031095, 00089031124, 00089031195, 00089031224, 00089031245, 00089031324, 00089031345, 50419045101, 50419045104, 50419045173, 50419045201, 50419045204, 50419045273, 50419045301, 50419045304, 50419045373, 50419045401, 50419045404, 50419045473, 54569436700, 54569436701