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Drug Name: Cycrin

Drug ID: 104

Nutritional Considerations

  • Extended use of Cycrin may cause deficiencies in folic acid, magnesium, zinc, some B vitamins and C. Supplementation may be helpful with long term use of this medication.

    1. Van Nostrand Reinhold: Oral contraceptives and nutrient interactions, 1988:38.
    2. Lindenbaum J, Whitehead N, Reyner F. Oral contraceptive hormones, folate metabolism, and the cervical epithelium. Am J Clin Nutr 1975;28:346-53.
    3. Frassinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr 1985;41(4):703.
    4. Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973;I:897-904.
    5. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-64.
    6. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-98.
    7. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-11 [review].
    8. Kornberg A, Segal R, Theitler J, et al: Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives, Isr J Med Sci, 1989, 25 (3): 142-5.
    9. Harper JM, Levine AJ, Rosenthal DL, et al: Erythrocyte folate levels, oral contraceptive use and abnormal cervical cytology, Acta Cytol, 1994, 38 (3): 324-30.
    10. Blum M, Kitai E, Ariel Y, Et Al: Oral Contraceptive Lowers Serum Magnesium, Harefuah, 1991, 121 (10):363-4.
    11. Seelig Ms, Interrelationship Of Magnesium And Estrogen In Cardiovascular And Bone Disorders, Eclampsia, Migraine, And Premenstrual Syndrome, J Am Coll Nutr, 1993, 12(4):442-58.
    12. Webb JL, Nutritional effects of oral contraceptive use, a review, J Reprod Med, 1980, 25 (4): 150-6.
    13. Prasad AS, Lei KY, Moghissi KS, et al: Effect of oral contraceptives on nutrients III--Vitamins B6, B12, and folic acid, Am J Obstet Gynecol, 1976, 125(8):1063-9.
    14. Bhagavan HN, Brin M: Drug-Vitamin B6 Interaction, Curr Concepts Nutr, 1983, 12:1-12.
    15. Kishi H, Kishi T, Williams RH, et al: Deficiency of vitamin B6 in women taking contraceptive formulations, Res Commun Chem Pathol Pharmacol, 1997, 17(2):283-93.
    16. Rivers JM: Oral contraceptives and ascorbic acid, Am J Clin Nutr, 1975, 28(5):550-4.
    17. Weininger J, King JC: Effect of oral contraceptive agents on ascorbic acid metabolism in the rhesus monkey, Am J Clin Nutr, 1982, 35(6):1408-16.
    18. Muneyvirci-Delale O, Nacharaju VL, Altura BM, et al: Sex steroid hormones modulate serum ionized magnesium and calcium levels throughout the menstrual cycle in women, Gertil Steril, 1998, 69(5):958-62.
  • Cycrin may cause levels of vitamin E, vitamin A, and calcium to increase. Discuss dietary considerations in relation to these increases with your physician or pharmacist.

    1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-11
    2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-64.
  • Limit caffeine intake. Hormonal agents may increase the effect of caffeine.

    1. Graedon J, Graedon, T: The People’s Guide to Deadly Drug Interactions, 1995
  • Use with care in diabetes, the drug may raise sugar levels.

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999

Herbal Considerations

  • The following herbs may affect hormone levels: Agnus castus (Vitex), Alfalfa, Bayberry, Black Cohosh, Dong Quai, Ginseng, Horseradish, Kelp, Licorice Root, Motherwort, Pleurisy Root, Red Clover, Red Sage, Saw Palmetto, Vervain, Wild Carrot Seed, and Wild Yam. Consult your pharmacist for more information.

    1. Ferguson T: The Smoker’s Book of Health, G.P. Putnam’s Sons, New York, 1987.
    2. Zava, DT: Estrogen and progetsin bioactivity of foods, herbs and spices. Proc. Soc. Exp. Biol. Med. 1998, 217:369-378.
    3. Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
    4. PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000

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