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Drug Name: Dapsone

Drug ID: 384

Nutritional Considerations

  • N-Acetyl-Cysteine - People taking isosorbide dinitrate might benefit from supplements of the amino acid N-acetyl-Cysteine. Controlled studies have shown that using intravenous and oral N-acetyl cysteine (NAC) reverses or prevents tolerance to nitrates.

    1. Boesgaard S, Aldershvile J, Poulsen HE. Preventive administration of intravenous N-acetylcysteine and development of tolerance to isosorbide dinitrate in patients with angina pectoris. Circulation 1992;85:143—9.
    2. Vincent J, Kongpatanakul S, Blaschke TF, Hoffman BB. Desensitization of nitrate-induced venodilation: reversal with oral N-acetylcysteine in humans. J Cardiovasc Pharmacol 1992;20:907—12
  • Another controlled study revealed that intravenous NAC enhanced the beneficial effects of ISDN on heart function.

    1. Mehra A, Shotan A, Ostrzega E, et al. Potentiation of isosorbide dinitrate effects with N-acetylcysteine in patients with chronic heart failure. Circulation 1994;89:2595—600.

NDC Codes

49938010101, 49938010201