Depakote
Written by YoMax
Drug Name: Depakote
Nutritional Considerations
Do not take this medication with sodas or any carbonated beverage. The carbonation could release valproic acid, which could greatly irritate the mouth and throat.
- Rybacki JJ. The Concise Essential Guide to Prescription Drugs, HarperCollins, 1997.
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
Depakote may cause deficiencies in the amino acid carnitine. Supplementation may be useful with long term use of the medication.
- Ohtani Y, Endo F, Matsuda I. Carnitine deficiency and hyperammonemia associated with valproic acid therapy, J Pediatr, 1982; 101:782-785.
- Van Wouwe JP. Carnitine deficiency during valproic acid treatment. Internat J Vit Nutr Res 1995;65:211-14.
- Farkas V, Bock I, Cseko J, et al: Inhibition of carnitine biosynthesis by valproic acid in rats - the biochemical mechanism of inhibition, Biochem Pharmacol, 1996, 52(9):1429-33.
- Matsuda I, Ohtani Y, Ninomiya N: Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy, J Pediatr, 1986, 109(1):131-4.
- Tein I, DiMauro S, Xie ZW, et al: Valproic acid impairs carnitine uptake in cultured human skin fibroblasts - an invitro model for the pathogenesis of valproic acid-associated carnitine deficiency, Pediatr Res, 1993, 34(3):281-7.
- Opala G, Winter S, Vance C, et al: The effect of valproic acid on plasma carnitine levels, Am J Dis Child, 1991, 145(9):999-1001.
- De Vivo DC, Bohan TP, Coulter DL, et al: L-carnitine supplementation in childhood epilepsy - current perspectives, Epilepsia, 1998, 39(11):1216-25.
- Castro-Gago M, Camina F, Rodriguezx-Segade S. Carnitine deficiency caused by valproic acid. J Pediatr 1992;120:496 [letter].
Depakote may also contribute to deficiencies in folic acid, vitamin E, and selenium Long-term usage of Depakote with vitamin D deficiency has been shown to cause osteomalacia. Supplementation may be beneficial.
- Hahn TJ, Halstead LR: Anticonvulsant drug-induced osteomalacia: alterations in mineral metabolism and response to vitamin D administration, Calcif Tiss Internat. 1979; 27:13-18.
- Mountain KR, Hirsch J, Gallus AS: Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy, Lancet, 1970; 1:265-268.
- Nurge ME, Anderson CR, Bates E. Metabolic and nutritional implications of valproic acid. Nutr Res 1991;11:949-60.
- Hendal J, et al. The effects of carbamazepine and valproate on folate metabolism. Acta Neurol Scand 69: 226-231, 1984.
Use of alcohol should be avoided.
- Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
Herbal Considerations
These herbs may increase the risk of seizures: Borage, Evening Primrose Oil, Ground Ivy and Sage.
- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996:21,45,63,282.
These herbs may have sedative properties and should be avoided: Chamomile (German), Ginsengs, Goldenseal, Hops, Hydrocotyle (Gotu Kola), Nettle, Passionflower, Sage, Skullcap, Shepherd’s Purse, St. John’s Wort, Valerian, Wild Carrot and Wild Lettuce.
- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996:21,45,63,282.
- PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
- The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
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