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Drug Name: Estrace

Drug ID: 159

Nutritional Considerations

  • Estrace may increase risk of folic acid deficiency, which could affect reproductive and cardiovascular health. Supplementation is considered beneficial with long term use of the medication.

    1. Roe DA. Nutrition and the contraceptive pill. In: Winick M, ed. Nutritional Disorders of American Women. New York: John Wiley and Sons; 1977:37-49.
    2. Lindenbaum J, Whitehead N, Reyner F. Oral contraceptive hormones, folate metabolism, and the cervical epithelium. Am J Clin Nutr 1975;28:346-53.
    3. Kornberg A, Segal R, Theitler J, et al: Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives, Isr J Med Sci, 1989, 25 (3): 142-5.
    4. Harper JM, Levine AJ, Rosenthal DL, et al: Erythrocyte folate levels, oral contraceptive use and abnormal cervical cytology, Acta Cytol, 1994, 38 (3): 324-30.
  • Estrace may affect absorption of the certain B vitamins, magnesium, and zinc. Supplementation of these nutrients may be beneficial with long term use of the medication.

    1. Zava, DT: Estrogen and progestin bioactivity of foods, herbs and spices. Proc. Soc. Exp. Biol. Med. 1998, 217:369-378.
    2. Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973;I:897-904.
    3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-98.
    4. Blum M, Kitai E, Ariel Y, Et Al: Oral Contraceptive Lowers Serum Magnesium, Harefuah, 1991, 121 (10):363-4.
    5. Seelig Ms, Interrelationship Of Magnesium And Estrogen In Cardiovascular And Bone Disorders, Eclampsia, Migraine, And Premenstrual Syndrome, J Am Coll Nutr, 1993, 12(4):442-58.
    6. Webb JL, Nutritional effects of oral contraceptive use, a review, J Reprod Med, 1980, 25 (4): 150-6.
  • Vitamin C may result in increased estrogen effects.

    1. Rybacki, JM. The Concise Guide to Prescription Drugs. Harper, 1997.
    2. Pronsky, Z Food Medication Interactions, 11th edition, 1999
  • Talk to your doctor about calcium supplementation, exercise, and periodic bone density screenings with long term use of the medication.

    1. Rybacki, JM. The Concise Guide to Prescription Drugs. Harper, 1997.
    2. Pronsky, Z Food Medication Interactions, 11th edition, 1999
  • Avoid grapefruit juice with this medication, it may increase drug levels.

    1. Schubert W, Cullberg G, Edgar B, Hedner T. Inhibition of 17 beta-estradiol metabolism by grapefruit juice in ovariectomized women. Maturitas 1994;20:155-63.

Herbal Considerations

  • The following herbs may affect hormone levels: Agnus Castus (Vitex), Alfalfa, Bayberry, Black Cohosh, Dong Quai, Ginseng, Horseradish, Kelp, Licorice Root, Motherwort, Pleurisy Root, Red Clover, Red Sage, Saw Palmetto, Vervain, Wild Carrot Seed, and WildYam. Many herbs many interact with hormone replacement. Consult your pharmacist for more information.

    1. Ferguson T: The Smoker’s Book of Health, G.P. Putnam’s Sons, New York, 1987.
    2. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
    3. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
    4. PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000

NDC Codes

00072994014, 00072994042, 00072994090, 00072994095, 00072994096, 00087002141, 00087075501, 00087075548, 00087075601, 00087075648, 15548002141, 15548002190, 15548075501, 15548075548, 15548075601, 15548075648, 19458077001, 19458077101, 49035009601, 49035009701, 54868049400, 54868049402, 54868049500