Text Size

Site Search powered by Ajax

Imipramine

Drug Name: Imipramine

Drug ID: 260

Nutritional Considerations

  • May take medication with food to decrease stomach upset.

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999
  • Limit or avoid caffeine in diet.

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999
    2. Bezchlidnyk, K.Z. : Should psychiatric patients drink coffee? Can. Med. Ass. J. 1981, Feb 15, 124:4.
  • Vitamin B1, B2 , B6 and Co-Q-10 may need to be supplemented with long term use of the medication.

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999
    2. Kishi T, et al: Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by Coenzyme Q10, Biomedical and Clinical Aspects of Coenzyme Q10, 1980, 2:139-54
    3. Bell IR, Edman JS, Morrow FD, et al: Brief communication - Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive function, J Am Coll Nutr, 1992, 11(2):159-63
  • Avoid alcohol

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999
    2. Hudson CJ: Tricyclic antidepressants and alcoholic blackouts. J Nerv Ment Dis 1981; 169:381.
    3. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
  • There may be an increase in apetite, particularly for sweets.

    1. Pronsky, Z Food Medication Interactions, 11th edition, 1999
    2. Paykel ES, Mueller PS & De la Vergne PM: Amitriptyline, weight gain and carbohydrate craving: a side effect. Br J Psychiatry 1973; 123:501.

Herbal Considerations

  • Tricyclic antidepressants may display additive anticholinergic effects with Thorn apple, (Jimsen weed).

    1. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
    2. Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
  • Tobacco speeds the elimination of tricyclic antidepressants.

    1. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
  • Tricyclic antidepressants and SAMe may interact to increase serotonergic side effects.

    1. Berlanga C, et al. "Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine." Psychiatry Res, 1992; 44(3):257-62.
    2. Iruela LM, et al. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psych 1993; 150:522.
  • Hypertension may occur with yohimbe and tricyclic antidepressants e.g. Imipramine

    1. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
  • Tricyclic antidepressants may decrease the effectiveness of Indian Snakeroot.

    1. McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  • The German Commission E has noted an interaction or possibility of an interaction between tricyclic antidepressants and these herbs: Belladonna leaf and root , Henbane leaf, Kava Kava, Scopolia root

    1. Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.

NDC Codes

00093211101, 00093211110, 00093211301, 00093211310, 00093211701, 00093211710, 00182082789, 00182082889, 00603404321, 00603404332, 00603404421, 00603404432, 00603404521, 00603404532, 00677042101, 00677042106, 00677042107, 00677042110, 00677042201, 00677042206, 00677042207, 00677042210, 00677042301, 00677042306, 00677042307, 00677042310, 00781176201, 00781176210, 00781176401, 00781176410, 00781176413, 00781176601, 00781176610, 00781176613, 00904092570, 00904092580, 00904092770, 00904092780, 00904092970, 00904092980, 49884005401, 49884005404, 49884005405, 49884005410, 49884005501, 49884005504, 49884005505, 49884005510, 49884005601, 49884005604, 49884005605, 49884005610, 51129144301, 51129144501, 51655014821, 51655014824, 51655014851, 51655014877, 53002106600, 53002106602, 53002106603, 53002106605, 53002106606, 53489033001, 53489033010, 53489033101, 53489033110, 53489033201, 53489033210, 53978007309, 54569019400, 54569019402, 54569019405, 54569019602, 54569019603, 54569019604, 54569272600, 54868134400, 54868134401, 54868134402, 54868134403, 54868222100, 54868222101, 54868222102, 54868222103, 54868222104