Lotrisone
Drug Name: Lotrisone
Drug ID: 100
Nutritional Considerations
Potent topical corticosteroid preparations, e.g., Lotrisone, in children may compromise the immune system and deplete several important nutrients. Discuss multivitamin supplementation with long term use with a pharmacist.
- AMA Drug Evaluations, 1995 Annual, American Medical Association.
- Drug Facts & Comparisons, February 1993, p. 589a.
- Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 83.
- Thelkeld DS, ed. Hormones, Adrenal Cortical Steroids, Glucocorticoids. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr 1991.
- Trovato A et al. Drug-nutrient interactions. Am Family Phys 1991;44:1651-58 [review].
- Chesney RW et al. Reduction of serum-1,25-dihydroxyvitamin-D, in children receiving glucocorticoids. Lancet 1978;ii:1123-25.
- Widmer P, Maibach R, Kunzi UP, et al: Diuretic-Related hypokalaemia - the role of diuretics, potassium supplements, glucocorticoids, and beta-2-adrenoceptor agonists - results from the Comprehensive Hospital Drug Monitoring program, Berne (CHDM), Eur J Clin Pharmacol, 1995, 49(1-2): 31-6.
- Shenfield GM, Knowles GK, Thomas N, et al: Potassium supplements in patients treated with corticosteroids, Br J Dis chest, 1975, 69:171-6.
- Gol’berg ED, Eshchenko VA, Bovt VD, et al: The effect of immunosuppressive substances on the zinc content in cells, Biull Eksp Biol Med, 1993, 116(10):412-3.
- Yunice AA, Czerwinski AW, Lindeman RD: Influence of synthetic corticosteroids on plasma zinc and copper levels in humans, Am J Med Sci, 1981, 282(2):68-74.
- Fodor L, Ahnefeld FW, Fazekas AT: Studies on the glucocorticoid control of zinc metabolism, Infusionsther Klin Ernahr, 1975, 2(3):210-3.
- Atkinson SA, Halton JM, Bradley C, et al: Bone and mineral abnormalities in childhood acute lymphoblastic leukemia - influence of disease, drugs, and nutrition, Int J Cancer Suppl, 1998, 11:35-9.
- Simeckova A, Neradilova M, Reisenauer R: Effect of prednisolone on the rat bone calcium, phosphorus, and magnesium concentration, Physiol Bohemoslov, 1985, 34(2):155-60.
- Frequin ST, Wevers RA, Braam M, et al: Decreased vitamin B12 and folate levels in cerebrospinal fluid and serum of multiple sclerosis patients after high-dose intravenous methylprednisone, J Neurol, 1993, 240(5):305-8.
- Peretz A, Neve J, Vertongen F, et al: Selenium status in relation to clinical variables and corticosteroid treatment in rheumatoid arthritis, J Rheumatol, 1987, 14(6):1104-7.
Herbal Considerations
Ephedra (Ma huang) may increase the clearance of Lotrisone and therefore decrease its effectiveness.
- Jubiz W, Meikle AW. Alterations of glucocorticoid actions by other drugs and disease states. Drugs 1979;18:113-21.
Licorice may affect the action of Lotrisone and should be avoided with the medication.
- Chen MF, Shimada F, Kato H, et al. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Japon 1990;37:331-41.
Aloe vera used topically may intensify the effects of topical steroids.
- Davis RH, Parker WL, Murdoch DP. Aloe vera as a biologically active vehicle for hydrocortisone acetate. J Am Podiatric Med Assoc 1991;81:1-9.
NDC Codes
00085080901, 00085092401, 00085092402, 19458071501, 53002097463, 53002097467, 53922092401, 53922092402
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