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Drug Name: Lotrisone

Drug ID: 100

Nutritional Considerations

  • Potent topical corticosteroid preparations, e.g., Lotrisone, in children may compromise the immune system and deplete several important nutrients. Discuss multivitamin supplementation with long term use with a pharmacist.

    1. AMA Drug Evaluations, 1995 Annual, American Medical Association.
    2. Drug Facts & Comparisons, February 1993, p. 589a.
    3. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 83.
    4. Thelkeld DS, ed. Hormones, Adrenal Cortical Steroids, Glucocorticoids. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr 1991.
    5. Trovato A et al. Drug-nutrient interactions. Am Family Phys 1991;44:1651-58 [review].
    6. Chesney RW et al. Reduction of serum-1,25-dihydroxyvitamin-D, in children receiving glucocorticoids. Lancet 1978;ii:1123-25.
    7. Widmer P, Maibach R, Kunzi UP, et al: Diuretic-Related hypokalaemia - the role of diuretics, potassium supplements, glucocorticoids, and beta-2-adrenoceptor agonists - results from the Comprehensive Hospital Drug Monitoring program, Berne (CHDM), Eur J Clin Pharmacol, 1995, 49(1-2): 31-6.
    8. Shenfield GM, Knowles GK, Thomas N, et al: Potassium supplements in patients treated with corticosteroids, Br J Dis chest, 1975, 69:171-6.
    9. Gol’berg ED, Eshchenko VA, Bovt VD, et al: The effect of immunosuppressive substances on the zinc content in cells, Biull Eksp Biol Med, 1993, 116(10):412-3.
    10. Yunice AA, Czerwinski AW, Lindeman RD: Influence of synthetic corticosteroids on plasma zinc and copper levels in humans, Am J Med Sci, 1981, 282(2):68-74.
    11. Fodor L, Ahnefeld FW, Fazekas AT: Studies on the glucocorticoid control of zinc metabolism, Infusionsther Klin Ernahr, 1975, 2(3):210-3.
    12. Atkinson SA, Halton JM, Bradley C, et al: Bone and mineral abnormalities in childhood acute lymphoblastic leukemia - influence of disease, drugs, and nutrition, Int J Cancer Suppl, 1998, 11:35-9.
    13. Simeckova A, Neradilova M, Reisenauer R: Effect of prednisolone on the rat bone calcium, phosphorus, and magnesium concentration, Physiol Bohemoslov, 1985, 34(2):155-60.
    14. Frequin ST, Wevers RA, Braam M, et al: Decreased vitamin B12 and folate levels in cerebrospinal fluid and serum of multiple sclerosis patients after high-dose intravenous methylprednisone, J Neurol, 1993, 240(5):305-8.
    15. Peretz A, Neve J, Vertongen F, et al: Selenium status in relation to clinical variables and corticosteroid treatment in rheumatoid arthritis, J Rheumatol, 1987, 14(6):1104-7.

Herbal Considerations

  • Ephedra (Ma huang) may increase the clearance of Lotrisone and therefore decrease its effectiveness.

    1. Jubiz W, Meikle AW. Alterations of glucocorticoid actions by other drugs and disease states. Drugs 1979;18:113-21.
  • Licorice may affect the action of Lotrisone and should be avoided with the medication.

    1. Chen MF, Shimada F, Kato H, et al. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Japon 1990;37:331-41.
  • Aloe vera used topically may intensify the effects of topical steroids.

    1. Davis RH, Parker WL, Murdoch DP. Aloe vera as a biologically active vehicle for hydrocortisone acetate. J Am Podiatric Med Assoc 1991;81:1-9.

NDC Codes

00085080901, 00085092401, 00085092402, 19458071501, 53002097463, 53002097467, 53922092401, 53922092402