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Norvir

Drug Name: Norvir

Drug ID: 286

Nutritional Considerations

  • Take with food.

    1. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
  • Grapefruit juice may enhance the pharmocologic effects of this drug.

    1. Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-I protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol. 1999;48:543-552
    2. Kupferschmidt HHT, Fattinger DE, Ha HR et al. Grapefruit juice enhances the bioavailability of the HIV protease inhibitor in man. Br J Clin Pharmacol 1998: 45: 355-9.

Herbal Considerations

  • The following herbs: Adonis, Digitalis lanata, English hawthorn, Lily-of-the-Valley, Scotch broom herb, and Squill have antiarrhythmic properties. Based on known interactions between norvir and antiarrythmics, these herbs should be avoided to decrease risk of adverse effects.

    1. PDR (Physician's Desk Reference) for Herbal Medicines. Second edition. Medical Economics Company. Montvale, NJ. 2000: 205, 259.
    2. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
  • Avoid St. John's Wort while taking protease inhibitors in view of the known interaction between St. John's Wort and Indinavir. St. John's Wort may decrease the blood levels of drug.

    1. Piscitelli SC, Burstein AH, Chaitt D, et al. Indinavir concentrations and St. John's wort. Lancet 355: 547-548, 2000.
    2. Risk of drug interactions with St. John's wort and indinavir and other drugs. URL: www.fda.gov/cder/drug/advisory/stjwort.htm
  • The following herbs: calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng Siberian, goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa have sedative or hynotic effects. In view of known interactions between certain sedative hynotics and norvir, consult your physician or pharmacist before using these herbs with norvir.

    1. PDR (Physician's Desk Reference) for Herbal Medicines. Second edition. Medical Economics Company. Montvale, NJ. 2000
    2. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
  • Astragalus may interact and enhance side effects of antiviral agents such as norvir.

    1. Upton R (ed). Astragalus Root: analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia; 1999;1-25
    2. Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000

NDC Codes

00074194063, 00074663322, 00074949202, 00074949254, 11014123301, 54569461300