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Ortho-Novum 7/7/7

Drug Name: Ortho-Novum 7/7/7

Drug ID: 61

Nutritional Considerations

  • Extended use of Ortho-Novum may cause deficiencies in folic acid, magnesium, zinc, and vitamins B2, B6, B12, and C. Supplementation may be beneficial with long term use.

    1. Van Nostrand Reinhold: Oral contraceptives and nutrient interactions, 1988:38.
    2. Lindenbaum J, Whitehead N, Reyner F. Oral contraceptive hormones, folate metabolism, and the cervical epithelium. Am J Clin Nutr 1975;28:346-53.
    3. Frassinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr 1985;41(4):703.
    4. Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973;I:897-904.
    5. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-64.
    6. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-98.
    7. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-11 [review].
    8. Kornberg A, Segal R, Theitler J, et al: Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives, Isr J Med Sci, 1989, 25 (3): 142-5.
    9. Harper JM, Levine AJ, Rosenthal DL, et al: Erythrocyte folate levels, oral contraceptive use and abnormal cervical cytology, Acta Cytol, 1994, 38 (3): 324-30.
    10. Blum M, Kitai E, Ariel Y, Et Al: Oral Contraceptive Lowers Serum Magnesium, Harefuah, 1991, 121 (10):363-4.
    11. Seelig Ms, Interrelationship Of Magnesium And Estrogen In Cardiovascular And Bone Disorders, Eclampsia, Migraine, And Premenstrual Syndrome, J Am Coll Nutr, 1993, 12(4):442-58.
    12. Webb JL, Nutritional effects of oral contraceptive use, a review, J Reprod Med, 1980, 25 (4): 150-6.
    13. Prasad AS, Lei KY, Moghissi KS, et al: Effect of oral contraceptives on nutrients III - Vitamins B6, B12, and folic acid, Am J Obstet Gynecol, 1976, 125(8):1063-9.
    14. Bhagavan HN, Brin M: Drug-Vitamin B6 Interaction, Curr Concepts Nutr, 1983, 12:1-12.
    15. Kishi H, Kishi T, Williams RH, et al: Deficiency of vitamin B6 in women taking contraceptive formulations, Res Commun Chem Pathol Pharmacol, 1997, 17(2):283-93.
    16. Rivers JM: Oral contraceptives and ascorbic acid, Am J Clin Nutr, 1975, 28(5):550-4.
    17. Weininger J, King JC: Effect of oral contraceptive agents on ascorbic acid metabolism in the rhesus monkey, Am J Clin Nutr, 1982, 35(6):1408-16.
    18. Muneyvirci-Delale O, Nacharaju VL, Altura BM, et al: Sex steroid hormones modulate serum ionized magnesium and calcium levels throughout the menstrual cycle in women, Gertil Steril, 1998, 69(5):958-62.
  • Ortho-Novum may cause levels of vitamin E, vitamin A, and calcium to increase. Discuss with your physician or pharmacist about dietary considerations pertaining to these increases.

    1. Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
    2. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-11 [review].
    3. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-64.
  • Caffeine intake should be limited. Hormonal contraceptive agents may increase the effect of caffeine.

    1. Graedon J, Graedon, T: The People’s Guide to Deadly Drug Interactions, 1995, p 133.
    2. Pronsky, Z Food Medication Interactions, 11th edition, 1999

Herbal Considerations

  • The following herbs possess antidiabetic properties that may be decreased if oral contraceptives are used in combination with them: Dandelion, Juniper, Nettle, and Onion plant.

    1. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
    2. PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
  • The following herbs may be hormonally active and could disturb the action of Ortho-Novum: Agnus Castus, Bayberry, Black Cohosh, Ginseng, Horseradish, Licorice, Motherwort, Saw Palmetto, Vervain and Wild Yam.

    1. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
    2. Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
  • Avoid cola, cocoa, green tea, guarana and mate with this medication due to their caffeine content.

    1. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998

NDC Codes

00062178115, 00062178117, 00062178120, 00062178122, 00062178127, 00062178131, 00107178115, 00107178117, 00107178120, 00107178127, 00179129803, 53808003203, 53808003206, 54868050800