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Prilosec

Drug Name: Prilosec

Drug ID: 6

Nutritional Considerations

  • This medication may affect the proper absorption of beta carotene, iron and vitamin B12. Consult your pharmacist regarding supplementation.

    1. Drug Interaction Facts, Tatro, D.S., Editor (St. Louis, MO, Facts and Comparisons, through July 1995)
    2. Bradford GS, Taylor CT: Omeprazole and vitamin B12 deficiency, Ann Pharmacother 1999 May;33(5):641-3.
    3. Termanini B, Gibril F, Sutliff VE, et al. Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. Am J Med 1998;104:422-30.
    4. Koop H, Bachem MG. Serum iron, ferritin, and vitamin B12 during prolonged omeprazole therapy. J Clin Gastroenterol 1992;14:288-92.
    5. Bellou A, Aimone-Gastin I, De Korwin JD, et al: Colbalamin deficiency with megaloblastic anemia in one patients under long-term omeprazole therapy, J Intern Med, 1996, 240(3): 161-4.
    6. Saltzman JR, Kemp JA, Golner BB, et al: Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption, J Am Coll Nutr, 1994, 13 (6):584-91.
    7. Pronsky, Z Food Medication Interactions, 11th edition, 1999
    8. Tang G, Serfaty-Lacronsniere C, Camilo ME, Russell RM. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-26.
  • Avoid alcohol with this drug.

    1. Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
    2. Pronsky, Z Food Medication Interactions, 11th edition, 1999

Herbal Considerations

  • Prilosec may interact with St. John's Wort to increase the risk of photosensitivity.

    1. Mirossay A, Mirossay L, Tothova, et al. Potentiation o fhypericin an dhypocrellin-induced phototoxicity by omeprazole. Phytomedicine 6(5): 311 - 317, 1999.
    2. Seigers Cp, et al. Phototoxicity caused by hypericum. Nervehielkunde 12: 320 - 322, 1993.
  • Acacia, Black mustard, Capsicum, Devil's Claw, Goldenseal,and Horseradish, all increase gastric acid and could therefore theoretically interact with Prilosec.

    1. PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000

NDC Codes

00006060607, 00006060628, 00006060631, 00006060668, 00006074207, 00006074228, 00006074231, 00006074307, 00006074328, 00006074331, 00006074368, 00006074382, 00179130060, 00186060607, 00186060628, 00186060631, 00186060668, 00186060682, 00186074207, 00186074228, 00186074231, 00186074282, 00186074307, 00186074328, 00186074331, 00186074368, 00186074382, 19458096209, 19458096309, 19458096409, 51129151501, 51129165001, 51129188601, 51129196801, 53978112903, 53978112905, 53978113005, 53978340905, 54569326700, 54569326702, 54868216900, 54868216901, 54868216902, 54868216903