Propranolol Hydrochloride
Written by YoMax
Drug Name: Propranolol Hydrochloride
Nutritional Considerations
Possible deficiencies include: Co-Q-10, and Chromium
- Kishi H, Kishi T, Folkers K: Bioenergetics in clinical medicine III - inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs, Res Commun Chem Pathol Pharmacol, 1975, 12(3):533-40
- Mountokalakis T, Dourakis S, Karatzas N, et al: Zinc deficiency in mild hypertensive patients treated with diuretics, J Hypertens Suppl, 1984, 2(3):S571-2
- Roeback JR Jr, Hla KM, Chambless LE, Fletcher RH. Effects of chromium supplementation on serum high-density lipoprotein cholesterol levels in men taking beta-blockers. A randomized, controlled trial. Ann Intern Med, 1991;115(12):917-924
Avoid alcohol.
- Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
Do not take propranolol with calcium or antacids. This may decrease absorption of the drug.
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
- Facts and Comparisons, Clinsphere 2.0, Wolters Kluwer Company, 2000
Avoid high doses of vitamin C (more than 2 grams/day) because it can decrease metabolism and absorption of the drug.
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
Use this medication with caution in diabetes because it can prolong hypoglycemia.
- Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
Herbal Considerations
Tobacco can reduce the effects of propranolol.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
Avoid natural licorice.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
These herbs may increase the side effects or adverse reactions of Propranolol due to their cardiac properties: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot
- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
- Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
- PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
Black cohosh, poplar, sweet birch, and wintergreen and willow bark all have salicylate properties which may interfere with beta blockers.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
Some herbs possess diuretic properties that may intensify the action of antihypertensive drugs. This could result in an excessive lowering of blood pressure. Such herbs include: Black Radish, Blue Cohosh, Cleavers, Couchgrass, Elder, Hops, Horsetail, Juniper, Black Safflower, and Sassafras
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
Ephedra should not be taken together with other CNS stimulants or circulatory agents (digitoxin, beta-blockers, etc.). Theoretically, a single high dose could result in irregular heartbeats.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
Cola, Guarana, Mate are some caffeine containing herbs that should be avoided with beta blockers.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
Melatonin can reverse the sleep effects of propranolol and atenolol.
- Stoschitzky K, Sakotnik A, Lercher P, et al. Influence of beta-blockers on melatonin release. Eur J Clin Pharmacol 1999;55(2):111-115
- Van Den Heuvel CJ, Reid KJ, Dawson D. "Effect of atenolol on nocturnal sleep and temperature in young men: reversal by pharmacological doses of melatonin." Physiol Behav, Jun. 1997; 61(6):795-802.
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