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Ranitidine Hydrochloride

Drug Name: Ranitidine Hydrochloride

Drug ID: 123

Nutritional Considerations

  • Ranitidine may increase the risk for iron and zinc deficiency. Discuss a supplementation plan with your physician.

    1. Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
    2. Hakanson R, Persson P, Axelson J: Elevated serum gastrin after food intake or acid blockade evokes hypocalcemia, Regul Pept, 1990, 28(2):131-6.
    3. Skikne BS, Lynch SR, Cook JD: Role of gastric acid in food iron absorption, Gastroenterology, 1981, 81(6):1068-71.
    4. Sturniolo GC, Montino MC, Rossetto L, et al: Inhibition of gastric acid secretion reduces zinc absorption in man, J Am Coll Nutr, 1991, 10(4):372-5.
  • Ranitidine may affect levels of folic acid and vitamin B-12. Supplementation may be beneficial. For optimal benefit, a B-Complex supplement is recommended.

    1. Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
    2. Force RW, Nahata MC: Effect of histamine-H2-Receptor antagonists on vitamin B12 absorption, Ann Pharmacother, 1992, 26(10):1283-6.
    3. Russell RM, Golner BB, Krasinski SD, et al: Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid, J Lab Clin Med, 1988, 112(4):458-63.
  • Use of alcohol and tobacco should be avoided.

    1. Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
    2. Lieber, CS: Mechanisms of ethanol-drug-nutrition interactions. J Toxicol Clin Toxicol 1994;32(6):631-81.
    3. Schurer-Maly CC, Varga L, Koelze HR, Halter F. Smoking and pH response to H2-receptor antagonists. Scand J Gastroenterol 1989;24:1172-78.
  • Limit amounts of caffeine, including chocolate, coffee, tea, and sodas. Avoid supplements that contain caffeine.

    1. Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999

Herbal Considerations

  • Avoid black tea, cocoa, coffee, cola nut, guarana, and mate because the caffeine can interfere with H2 antagonists.

    1. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
  • Licorice may theoretically provide an added protective effect with H2 antagonists.

    1. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998

NDC Codes

49884064702, 49884064811, 50962020359, 50962020360