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Vioxx

Drug Name: Vioxx

Drug ID: 294

Nutritional Considerations

  • Avoid large doses of vitamin E and NSAID's together, there may be a possible risk of increased bleeding.

    1. Liede KE, Haukka JK, Saxen LM, et al. Increased tendency toward gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30: 542-546, 1998.

Herbal Considerations

  • Deglycyrrhizinated licorice may be a stomach protectant when NSAID's are used long term.

    1. Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 14: 605-607, 1979.
    2. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
  • Avoid using ginkgo with NSAID's due to their potential to increase bleeding.

    1. Rosenblatt M and Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 336(15): 1108, 1997.
    2. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
    3. Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996; 46: 1775-76
  • Avoid these herbs with NSAID's like Vioxx due to their potential to increase bleeding times: dong quai, feverfew, garlic, ginger, horse chestnut, and red clover.

    1. Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
    2. Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
    3. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
  • Merck & Co. withdrew Vioxx worldwide after post market studies confirm that Vioxx raises the risk of serious cardiovascular events including heart attack and stroke. About 2 million people worldwide were on the drug at the time of its withdrawal. In addition to heart attacks and strokes, Vioxx has been associated with several other life-threatening side effects, including blood clots, angina and nonbacterial meningitis, severe intestinal damage, ulcerations and bleeding, and kidney damage.

    NDC Codes

    00006007404, 00006007428, 00006007430, 00006007431, 00006007468, 00006007480, 00006007482, 00006011004, 00006011028, 00006011030, 00006011031, 00006011068, 00006011080, 00006011082, 00006011401, 00006011402, 00006011428, 00006011430, 00006011431, 00006011468, 00006011474, 00006011481, 00006378464, 00006378564, 00615458831, 00615458863, 51129160501, 51655074524, 51655074584, 54569475800, 54569475801, 54569475900, 54569475901, 54569475902, 54569475903, 54569494000, 54569494001, 54569494002, 54569494003