Vioxx
Written by YoMax
Drug Name: Vioxx
Nutritional Considerations
Avoid large doses of vitamin E and NSAID's together, there may be a possible risk of increased bleeding.
- Liede KE, Haukka JK, Saxen LM, et al. Increased tendency toward gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30: 542-546, 1998.
Herbal Considerations
Deglycyrrhizinated licorice may be a stomach protectant when NSAID's are used long term.
- Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 14: 605-607, 1979.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
Avoid using ginkgo with NSAID's due to their potential to increase bleeding.
- Rosenblatt M and Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 336(15): 1108, 1997.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
- Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996; 46: 1775-76
Avoid these herbs with NSAID's like Vioxx due to their potential to increase bleeding times: dong quai, feverfew, garlic, ginger, horse chestnut, and red clover.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
- Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
Merck & Co. withdrew Vioxx worldwide after post market studies confirm that Vioxx raises the risk of serious cardiovascular events including heart attack and stroke. About 2 million people worldwide were on the drug at the time of its withdrawal. In addition to heart attacks and strokes, Vioxx has been associated with several other life-threatening side effects, including blood clots, angina and nonbacterial meningitis, severe intestinal damage, ulcerations and bleeding, and kidney damage.
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