Abstracts
Cancer & Senna
Cancer
Senna, a strong laxative, has been associated with an increased risk for colorectal cancer. According to this study, sennosides (chemicals found in senna) cause massive cell loss in the intestinal wall. The body responds to such loss by increasing cellular proliferation and inhibiting programmed cell death (apoptosis), creating a perfect scenario for growth of cancer cells. To prove this hypothesis, researchers treated 32 randomized patients with sennosides or placebo and took biopsies of each colon. The senna-treated colons exhibited shorter crypts, which were associated with increased cell proliferation and presence of apoptotic factors.
van Gorkom BA, et al: Influence of a highly purified senna extract on colonic epithelium, Digestion 2000;61(2):113-20
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