Abstracts
Vitamin C (Capillary Fragility)
Vitamin C
Reviews the scientific evidence regarding the "vitamin C" status of people with "diabetes mellitus" and whether they might have increased dietary vitamin C requirements. English language articles published from 1935 to the present that either compare "ascorbic acid" concentrations of persons with and without "diabetes" mellitus or assess the impact of vitamin C supplementation on various health outcomes among persons with diabetes mellitus were examined. Most studies have found people with diabetes mellitus to have at least 30% lower circulating ascorbic acid concentrations than people without diabetes mellitus.
Vitamin C supplementation had little impact on "blood glucose" concentrations, but was found to lower cellular "sorbitol" concentrations and to reduce "capillary fragility". Much of the past research in this area has been methodologically weak. To further understand the relation of ascorbic acid and diabetes mellitus, randomized clinical trials of ascorbic acid supplementation should be a high priority for research.
Will JC & Byers T: Does diabetes mellitus increase the requirement for vitamin C? Nutr Rev, 1996 Jul, 54:7, 193-202.
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