Abstracts
Diet HPV (Cervical Dysplasia)
Diet HPV
According to this study, a diet low in vitamin C, beta-carotene, and folacin may be associated with a high cancer risk from HPV infections. In 228 females with normal cytological smear compared to 324 patients with cervical intraepithelial neoplasia (CIN), a control group of 168 HPV-negative patients with normal pap smears and a group of 228 HPV-positive females with CIN were selected. It was shown that women with cervical dysplasia associated with high cancer risk from HPV infections consumed a smaller quantity of foods containing vitamin C, beta-carotene and folacin.
Kwasniewska, Anna, et al: Dietary Factors in Women With Dysplasia Colli Uteri Associated With Human Papillomavirus Infection, Nutrition and Cancer, 1998;30(1):39-45.
Beta-Carotene (1)
Beta-Carotene (1)
Cervicovaginal cells and plasma "beta-carotene" levels were assessed.
They were found to be significantly decreased in women with cervical intraepithelial "neoplasia" and "cervical cancer", as compared with controls.
Beta-carotene deficiency may have an etiologic role in the development of cervical intraepithelial neoplasia and/or cervical "cancer".
"B-Carotene Levels in Exfoliated Cervicovaginal Epithelial Cells and Cervical Intraepithelial Neoplasia and Cervical Cancer", Palan, P et al., Am. Journal of Obstetrics & Gynecology, December 1992;167(6):1899-1903.
Beta-Carotene (2)
Beta-Carotene (2)
Evaluated the efficacy of beta-carotene to cause regression of CIN.
9 of 39 (23%) subjects in the beta-carotene group versus 14 of 30 (47%) in the placebo group had regression of CIN.
After controlling for these factors, the beta-carotene and placebo groups did not differ in risk for having CIN at 9 months.
Romney SL et al., Effects of beta-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection. Gynecol Oncol, 1997 Jun, 65:3, 483-92.
Oral Contraceptive Use
Oral Contraceptive Use
Seven hundred and fifty-nine cases of invasive cervical cancer and 1430 controls in Central and South America were evaluated for the risk cancer of from oral contraceptive use. Overall use was associated with a 21% nonsignificant elevation risk with some further increases in risk for more extensive use. Recent long term users were at highest risk. The risk associated with "oral contraceptives" was significantly increased for adenocarcinomas whereas for squamous "cell" "tumors" the effect was minimal. These results provide some support for an adverse effect of oral contraceptives on cervical cancer risks.
"Oral Contraceptive Use and the Risk of Invasive Cervical Cancer", Brinton, LA. et al, Intl. Journal of Epidemiology, 1990;19(1):4-11.
Undernutrition
Clinical evaluation of nutritional status (NS) was performed in 75 rheumatoid arthritis patients.
Patients in more severe radiological stages (Radiological Stage III and IV) or patients with extraarticular disease also presented a significant loss of LBM compared with a matched cohort of the general population and patients with a more benign-course disease.
There was less impairment of the fat mass, according to our clinical evaluation.
Serological parameters of undernutrition (albumin and transferrin) did not show significant differences among the groups of patients. Clinical evaluation of NS in RA patients is a useful procedure for recognising patients at high risk of related complications by means of their poor nutritional status.
Hernandez-Beriain JA et al., Undernutrition in rheumatoid arthritis patients with disability. Scand J Rheumatol, 1996, 25:6, 383-7.
Vitamins (Cervical Dysplasia)
Vitamins
Since the 1950's, the incidence of mortality rates from invasive cervical cancer have been reduced. It is estimated that there were 13,500 new cases of invasive cervical cancer, with 4,400 deaths, in 1992. Risk factors for cervical intraepithelial neoplasia (CIN) include multiple sex partners, possibly women married to men who have had multiple sex partners, "cigarette" "smoking", the human papilloma "virus" "infection", and dietary factors. Dietary factors which increase the risk include low "blood" and dietary carotenoids, vitamin C, and "folic acid".
Those with the highest levels of serum and dietary lycopene and dietary vitamin C, compared to the lowest, were 4 to 5 times more likely not to have CIN. Folic acid deficiency is a major problem worldwide. "Folate" is rich in fruits, vegetables, and whole grains, and is destroyed through food processing.
None of the individuals in this study showed signs of a macrocytic or "megaloblastic anemia" which is the hallmark of folate deficiency.
"The Role of Vitamins in the Development of Cervical Cancer", VanEenwyk, Juliet, The Nutrition Report, January 1993;11(1):1,8.
Vitamins A and E
Vitamins A and E
Serum "vitamin A" levels did not differ but "vitamin E" levels were significantly decreased in two of the cancer groups versus the controls. Vitamin E's protective benefit as a "free radical scavenger" in cancer.
"Vitamin A, Vitamin E and The Risk of Cervical Intraepithelial Neoplasia", Cuzick, J., et al, British Journal of Cancer, 1990;62: 651-652.
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