DMAE
Description
Dimethyl Amino Ethanol (DMAE) is one of the classic "Smart Nutrients" having been discussed in the original Smart Drugs & Nutrients book. DMAE occurs naturally in some foods notably fish.
Indeed, Dimethyl Amino Ethanol (DMAE) lends support to the old wives’ tale that fish is a great brain food. DMAE is normally present in small amounts in our brains, and is known for its mental stimulation and enhancement.
Because fish is naturally abundant in DMAE, a diet high in sardines and anchovies will provide higher than average levels of DMAE and choline to the brain, which serve as precursors (raw materials) for the production of the neurotransmitter acetylcholine.
Method of Action
Acetylcholine is responsible for conducting nerve impulses within the brain, and by accelerating the brain’s synthesis of this important neurotransmitter, DMAE may aid in improving memory and learning, as well as preventing loss of memory in adults.
Its antioxidant properties reduce lipofuscin deposits in the brain and skin.
Benefits
DMAE helps elevate mood, improve memory and learning, increase intelligence and physical energy, and extends the life span of laboratory animals.
It is used by many people for its mild, stimulant effect, yet DMAE also helps people to get to sleep. Many people report less fatigue in the day and sounder sleep at night, as well as needing less sleep, when taking DMAE.
Usage
Numerous scientific studies show that DMAE may help:
Antiaging effects:
· Extends the lifespan of laboratory animals.
· Hyperactivity treatment in children.
· Decreases fatigue in the day while providing for sounder sleep at night.
· Increases intelligence.
· Improves memory.
· Elevates mood and learning.
· Increase physical energy.
Sleep:
·make it easier for most people to get to sleep
·decrease fatigue in the day while providing for sounder sleep at night
·reduce the need for sleep
·enhance lucid dreams
· Provides a mild, safe tonic effect.
· Enhances "vigilance" (increases alertness and responsiveness)
Safety & Toxicity
Dosage: take 1 - 4 capsules per day
Advisable to start with 1 capsule and working your way up to 4 per day. It may take 2 weeks before the effects are felt.
Is it DMAE or DMAE Bitartrate?
Each capsule contains 340-mg of DMAE Bitartrate (the salt form of DMAE). The Bitartrate salt contains 35% active DMAE. Thus, if a label says 125-mg of DMAE Bitartrate, it really only has 45-mg DMAE in it.
When DMAE use is discontinued, no depression or let-down occurs.
It is generally recognized as safe for over-the-counter sales.
Research Briefs
Memory performance
Nicotine has been found to improve memory performance in a variety of tests, including the radial-arm maze. This improvement, together with the consistent finding of a decline in cortical nicotinic receptor concentration in Alzheimer's patients, has fueled the search for novel nicotinic ligands with therapeutic potential.
One of the 3 compounds tested, DMAE II (dimethylaminoethanol cyclohexyl carboxylate fumurate), produced significant improvements in working memory performance.
In the first experiment, this drug produced a biphasic dose-response curve with improved performance at the 20-mg/kg dose but not at 10 or 40 mg/kg. In a second round of DMAE II administration, the same rats showed a significant improvement with the 40-mg/kg dose.
In the second experiment, a new set of rats also showed a biphasic dose-response to DMAE II. The 20-mg/kg dose caused a significant improvement whereas the 40-mg/kg dose did not.
Nicotine (0.2 mg/kg) by itself caused a significant improvement in working memory performance. No additive effects of DMAE II with nicotine were seen. In fact, some attenuation of response was seen with the combination.
Like nicotine, the nicotinic ligand DMAE II causes an improvement in radial-arm mace choice accuracy. The lack of additivity with nicotine may have been to the partial agonist effects of DMAE II.
Levin ED et al., Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze. Pharmacol Biochem Behav, 1995 Jun, 51:2-3, 369-73.
References:
Levin ED et al., Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze. Pharmacol Biochem Behav, 1995 Jun, 51:2-3, 369-73.
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