Abstracts
Biotransformation
Biotransformation
Para-aminobenzoic acid (PABA) is an essential cofactor for the production of folic acid in bacteria and has mild anti-inflammatory activity.
Background studies with the salicylate group of drugs suggested that PABA might be similarly metabolized by Polymorphonuclear Neutrophils (PMN). In these studies, we demonstrate that PABA is metabolized by stimulated PMN. However, in contrast to the biochemical mechanism involved in the metabolism of salicylate, our scavenger studies indicate that PABA is metabolized primarily by the myeloperoxidase pathway. Our results may explain the mild anti-inflammatory actions of the drug and suggest that the degradation of PABA by PMN at an inflammatory site may limit the availability of PABA for bacterial growth.
Biotransformation of para-aminobenzoic acid and salicylic acid by PMN. Sagone-AL Jr; Husney-RM; Davis-WB. Free-Radic-Biol-Med; 1993 Jan; 14(1); P 27-35.
Embryonic Development
Embryonic Development
Injection of low-dose (5mg/kg) para-aminobenzoic acid (PABA) into pregnant rats does not exert a damaging effect on fetal development, according to this study. At doses 5 and 15 mg/kg, PABA does not affect growth but reduces the scattering of the extreme values of the parieto-coccygeal size and body mass, thus reflecting normalization of the growth of fetuses within the litter. At a dose of 50 mg/kg, the increase of body mass of the fetuses is insignificantly diminished (p < 0.05), which is usually normalized during postnatal development.
Stroeva OG; Popov VB: Effect of para-aminobenzoic acid on the development of rat embryos when applied to pregnant females, Ontogenez, 1998 Nov-Dec; 29(6):444-9
LPO
LPO
This study examines the effect of para-aminobenzoic acid (PABA) on lipid peroxidation (LPO) in rat and guinea pig retina exposed to hypoxic hypoxia. PABA was injected intraperitoneally and parabulbarly before and after hypoxic exposure. Antioxidant activities of PABA and emoxipin were compared. An intraperitoneal injection of PABA before hypoxia virtually completely prevented accumulation of lipid peroxides and preserved catalase activity in the retina. Parabulbar injection of PABA solution before hypoxia prevented LPO intensification, stabilized catalase activity in hypoxia, and protected the retina starting from the moment immediately after hypoxic exposure. PABA exerts an antioxidant effect after hypoxia by decreasing the abnormally high level of lipid peroxides and reducing catalase activity in the retina after parabulbar injection of the drug. All the studied concentrations of the drug (from 0.007 to 0.08%) are active, but the optimal dose for the retina is 0.04%.
Akberova SI; Musaev Galbinur PI; Magomedov NM; Babaev KhF; Gakhramanov KhM; Stroeva OG:
Comparative assessment of antioxidant activity of para-aminobenzoic acid and emoxipin in retina, Vestn Oftalmol, 1998 Nov-Dec; 114(6):39-44
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