Abstracts
Alzheimer's Disease
Alzheimer's Disease
Memory loss and Alzheimer's disease can be prevented and reversed with an integrated medical approach, according to this study, based on research and clinical observations. The authors associate a high-fat diet, chronic unbalanced stress with its attendant risk in the adrenal hormone cortisol, and the presence of cardiovascular disease with the development of memory loss and connected diseases. The authors then present a 4-pillar integrative program, which includes a diet consisting of 15% fat and supplementation with brain-specific nutrients such as vitamin B complex, vitamin E, ubiquinone, ginkgo biloba, and phosphatidylserine. In addition, stress-relieving meditation, mind-body and cognitive exercise, antiaging drugs like L-deprenyl citrate, as well as hormones such as dehydroepiandrosterone and pregnenolone complete the program. Patient benefits such as greater wisdom and spiritual happiness are also explored.
Khalsa DS: Integrated medicine and the prevention and reversal of memory loss, Altern Ther Health Med, 1998 Nov; 4(6):38-43
Antinociceptive
Antinociceptive
Additive analgesic effects of long-term application of a combination of the vitamins B1, B6, B12 (thiamine diphosphate 100 mg, pyridoxsine-HCl 200 mg, cyanocobalamin 20 micrograms, p.o.) on a single dose of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac (diclofenac-Na, 50 mg, p.o.) were investigated with a noninflammatory experimental pain model in volunteers (#38).
B-vitamins were given with 3 dosages/day for 1 week. Then experimental sessions of 3 h followed to test the analgesic efficacy of the NSAID. In these sessions, phasic pain was induced by intracutaneously applied brief electrical pulses (20 ms). Measured were the pain ratings, the cerebral potentials and the EEG delta power in responses to the stimuli as target variables for the analgesic test.
No B-vitamin effects of the B-vitamins could be detected, either additive analgesic effects on diclofenac analgesia or on the concomitant variables describing unspecific sedative effects. Clearly the B-vitamin pretreatment for 1 week enlarged the plasma levels for vitamin B6 by 700%, for vitamin B1 by 70% and for vitamin B12 by 50%. All B-vitamin concentrations were independent of each other.
Do the B-vitamins exhibit antinociceptive efficacy in men? Results of a placebo-controlled repeated-measures double-blind study. Bromm-K; Herrmann-WM; Schulz-H. Neuropsychobiology. 1995; 31(3): 156-65.
Antioxidative
Antioxidative
The objective of this study was to evaluate the antioxidative properties of the multivitamin cocktail Omnibionta (alpha-tocopherol, ascorbic acid, retinol, vitamin B complex) in terms of diminishing lipid peroxidation with improvement of leg edema performance after limb revascularization operations in humans. Fifty-one subjects were selected; the control group contained 27 patients and the treatment group 24 patients, who received the vitamin cocktail intravenously before the start of reperfusion. All patients suffered from acute or chronic arterial occlusive disease, except two subjects with arterial trauma.
Results suggest that antioxidative vitamin treatment might be valuable in preventing lipid peroxidation and decreasing extremity edema.
Antioxidative vitamin treatment: effect on lipid peroxidation and limb swelling after revascularization operations. Rabl-H; Khoschsorur-G; Petek-W. World-J-Surg. 1995 Sep-Oct; 19(5): 738-44.
Elderly and diet
Elderly and diet
Physical changes in the elderly may require nutritional supplementation and dietary modification in order to prevent frail health, according to this study. The daily intake of B-Complex and vitamin C seems most important, as these vitamins are most often deficient in elderly people. In addition, immobile elderly and elderly of 75 years and older are at risk for an inadequate vitamin D status. An adequate diet is one of the factors that may prevent frail health. Currently, a change of the body weight is the best warning of insufficient nutrition.
Van Staveren WA; De Groot CP: [Changes in the energy needs of the elderly: an often encountered cause of nutritional deficiencies and frailty], Ned Tijdschr Geneeskd, Oct. 1998; 142(44):2400-4
Salmonella
Salmonella
B-Complex vitamins may contribute to immunity toward the Salmonella enteritidis bacteria, according to this study. Six trials were conducted during which a total of 12 congenic lines homozygous for various B-complex haplotypes, were challenged as neonates by intraperitoneal injection with either of two isolates of Salmonella enteritidis. Because these B haplotypes were expressed on a common genetic background, and mortality differences among lines were statistically significant in three of the six trials, and morbidity differences were significant in another trial; it is suggested that B-complex alleles affect the degree of immunity to these isolates. The results provide additional evidence for the importance of the B-complex in determining immunity to Salmonella.
Cotter PF; Taylor RL Jr; Abplanalp H: B-complex associated immunity to Salmonella enteritidis challenge in congenic chickens, Poult Sci, 1998 Dec; 77(12):1846-51
Glaucoma
Evidence is presented that the characteristic pattern of neuronal degeneration associated with glaucoma is due to a combination of the persistent physical damage to axons at the level of the lamina cribrosa and the associated neuronal reaction to this kind of trauma.
The class of neuronal cytoskeletal proteins known as the neurofilament triplet are crucially involved in the reaction to physical damage and the selective localization of these proteins to larger retinal ganglion cells may underlie their susceptibility to eventual degeneration.
The appearance of glaucoma-like neuronal pathology in Alzheimer's disease may follow the reaction of neurofilament-containing retinal ganglion neurons to persistent damage to their axons by beta-amyloid plaque formation in subcortical visual centers.
Vickers JC: The cellular mechanism underlying neuronal degeneration in glaucoma: parallels with Alzheimer's disease. Aust N Z J Ophthalmol, 1997 May, 25:2, 105-9.
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