Abstracts
Short Gut Syndrome
Short gut syndrome
Cysteine HCl, a plasma sulfur amino acid, may alleviate short gut syndrome among children receiving parenteral nutrition. Cysteine HCl with a pediatric amino acid solution increased taurine concentrations to within the normal range. Cysteine HCl normalizes plasma taurine concentrations in children on parenteral nutrition.
Helms, RA; Storm, MC; Christensen, ML; Hak, EB; Chesney, RW: Cysteine supplementation results in normalization of plasma taurine concentrations in children receiving home parenteral nutrition, J-Pediatr. 1999 Mar; 134(3): 358-61
Glutathione Depletion
Glutathione depletion
Glutathione depletion may have deleterious effects on host defense against oxidative damage, for it induces ornithine decarboxylase activity and increases in polyamine concentrations. Cysteine supplementation can increase glutathione concentrations of the small intestine and colon of parenterally fed newborn rabbits. Cysteine is not found in most total parenteral nutrition (TPN) formulas, and premature infants may not be able to synthesize cysteine due to a cystathionase deficiency. Total parenteral nutrition was administered to newborn rabbits with or without cysteine supplementation. Maternally reared rabbits were also studied. Total glutathione concentrations in the gastrointestinal tract were significantly reduced among newborn rabbits administered with cysteine-free TPN than those receiving cysteine or were reared maternally. Polyamine concentrations were similar among all groups. Cysteine-free parenteral nutrition leads to glutathione depletion of the small intestine and colon, which may weaken intestinal defense against oxidative damage.
Pollack, PF; Rivera, A Jr; Rassin, DK; Nishioka, K: Cysteine supplementation increases glutathione, but not polyamine, concentrations of the small intestine and colon of parenterally fed newborn rabbits, Pediatr-Gastroenterol-Nutr. 1996 May; 22(4): 364-72
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