Acetaminophen
Generic and Trade Names:
Acetaminophen Aspirin Free Anacin
Aspirin Free Excedrin,Feverall,Panadol
Tempra,Tylenol
Description:
Acetaminophen is the major constituent of a large group of well-known drugs, present in most households.
It is an alternative to aspirin (acetylsalicylic acid) , possessing some of the same analgesic and antipyretic properties. Note, it is not as useful in inflammatory conditions.
Nutritional Considerations:
Limit alcohol intake . (Pronsky 1999)
Herbal Considerations:
Milk Thistle Extract helps prevent liver damage from hepatotoxins, including acetaminophen (Campos 1989)(Brinker 1998).
Tobacco decreases blood levels of acetaminophen. (Brinker 1998)
References
Barker JD Jr, de Carle DJ & Anuras S: Chronic excessive acetaminophen use and liver damage. Ann Intern Med 1977; 87:299-301.
Brinker, Francis N.D. Herb Contraindications and Drug Interactions. 2nd edition. Eclectic Medical Publications. 1998
Campos, R. et al. (1989) Silybin Dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Medica. 55:417.
Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 1999.
Licht H, Seeff LB & Zimmerman HJ: Apparent potentiation of acetaminophen hepatotoxicity by alcohol. Ann Intern Med 1980; 92:511.
Lieberman, S. & Bruning, N.: The Real Vitamin & Mineral Book. Avery, NY.
McClain CJ, Kromhout JP, Peterson FJ et al: Potentiation of acetaminophen hepatotoxicity by alcohol. JAMA 1980; 244:251-253.
Pronsky, Zaneta. Food Medication Interactions. 11th edition. 1999
Seeff LB, Cuccherini BA, Zimmerman HJ et al: Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. Ann Intern Med 1986; 104:399-404.
Threlkeld DS, ed. Central Nervous System Drugs, Acetaminophen. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1997.
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