Anti Adrenergic - Peripheral
Generic and Trade Names:
| Guanadrel sulfate | Hylorel | |
| Guanethidine | smelin | |
| Rauwolfia Alkaloid | Reserpine, Serpasil | |
| Doxazosin | Cardura | |
| Prazosin | Minipress | |
| Terazosin | Hytrin |
Description:
These agents are used in the treatment of hypertension. They work in various ways to control blood pressure. Reserpine depletes the stores of catecholamines, epinephrine and norepinephrine from peripheral tissue sites. The alpha adrenergic blockers like terazosin dilate blood vessels and block post-synaptic adrenergic receptors which then results in decreased blood pressure. (Facts and Comparisons 1999)
Guanethidine is a dual-purpose prescription drug classified both as an antihypertensive and for the treatment of glaucoma.
Terazosin hydrochloride is a dual purpose drug, it is also used in the treatment of benign prostatic hyperplasia.
Nutritional Considerations:
A low sodium and low calorie diet may be prescribed (there is a tendency to gain weight).
Alcohol should be avoided (Pronsky 1999).
Hytrin may contribute to the depletion of CoQ10 and vitamin B6. Supplementation may be beneficial. (Kishi 1975)
Herbal Considerations:
Avoid natural licorice products. (Brinker, 1998)
Diuretics like: Carrot Seed, Cleavers, European Goldenrod, Figwort, Goat's Rue, Greater Celandine, Ground Ivy, Guaiac, Hemp, Hops, Horsetail, Juniper, Lovage, Marshmallow, Matico, Melilot, Mouse Ear, Nettle, Onion, Orris, Parsley Plant, Pellitory Of The Wall, Pipsissewa, Plantain, Pleurisy Root, Prickly Ash, Pulsatilla, Queen of the Meadow, Black Radish, Ragwort, Safflower, Sassafras, Saw Palmetto, Skunk Cabbage, Squaw Vine, Squill, Sweetflag, Thuja, Wahoo and Wormseed may potentiate the action of peripheral adrenergic blocking drugs. (Blumenthal 1998)
Ground Ivy, Kelp, Motherwort, Shizandra, Wild Indigo and Wormseed are synergistic with adrenergic agents. The major concern, with any such combination, would be over-stimulation, which in excess could result in a nervous breakdown. (Blumenthal 1998)
Ephedra (Ma Huang) enhances the sympathomimetic effect of Guanethidine. (Blumenthal 1998)
References
Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 1999.
Kishi H, Kishi T, Folkers K: Bioenergetics in clinical medicine III - inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs, Res Commun Chem Pharmacol, 1975, 12(3):533-40.
Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
PDR (Physicians Desk Reference). 49th Edition. Medical Economics Co. Montvale, NJ. 1995.
Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999.
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