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Abstracts

Brewer's Yeast Classification

Classification

Three alpha-glucosidases which passed under the names of transglucosidase (from Aspergillus niger), maltase (from Brewers yeast), and isomaltase (from Bakers yeast) for reasons of their substrate specificities and transfer actions, were purified to electrophoretically pure states.

Classification of some alpha-glucosidases and alpha-xylosidases on the basis of substrate specificity. Yoshikawa-K; Yamamoto-K; Okada-S. Biosci-Biotechnol-Biochem. 1994 Aug; 58(8): 1392-8.

Fever & Brewer's Yeast

Fever

The aim of the present work was to document the possible influence of the time of administration of brewer's yeast on a model of fever previously reported. The effect of brewer's yeast was different according to the hour of its administration.

During the 4 h following injection, brewer's yeast may induce hyper- or hypothermia.

Bruguerolle-B; Roucoules-X: Time-dependent changes in body temperature rhythm induced in rats by brewer's yeast injection. Chronobiol-Int. 1994 Jun; 11(3): 180-6.

Lithium & Brewer's Yeast

Lithium

A total of 24 subjects, 16 males and 8 females, average age 29.4 +/- 6.5 y, were randomly divided into two groups. Group A received 400 micrograms/d of lithium orally, in tablets composed of a naturally lithium-rich brewer's yeast, for 4 wk. Group B was given normal, lithium-free brewer's yeast as a placebo. All the subjects of the study were former drug users (mostly heroin and crystal methamphetamine). Some of the subjects were violent offenders or had a history of domestic violence. The subjects completed weekly self-administered mood test.

In the lithium group, the total mood test scores increased steadily and significantly during the period of supplementation.

In Group B, the combined mood test scores showed no consistent changes during the same period.

It is concluded that lithium at the dosages chosen had a mood-improving and -stabilizing effect.

Brewer's yeast supplementation had beneficial effects both on serum triacylglycerol and on 60-min and 90-min glucose values.

Schrauzer-GN; de-Vroey-E: Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users. Biol-Trace-Elem-Res. 1994 Jan; 40(1): 89-101

Gastrointestinal Disease

Gastrointestinal Disease

According to this study, antibodies to yeast organisms, Saccharomyces cerevisiae (sacc) may determine the yeast specific immune response in gastrointestinal disease. Specific antibody concentrations were compared between healthy controls and patients with Crohn's disease, ulcerative colitis, indeterminate colitis, chronic liver disease, coeliac disease, and irritable bowel syndrome. Patients with Crohn's disease had raised IgG and IgA anti-sacc antibodies. Among all Crohn's disease patients, serum glycoprotein was determined to be a significant indicator of the presence of both IgG and IgA antibodies. These results indicate that the antibodies from yeast organisms might signal certain immune response in Crohn's disease.

Darroch CJ, Barnes RM, Dawson J: Circulating antibodies to Saccharomyces cerevisiae (bakers'/brewers' yeast) in gastrointestinal disease, J Clin Pathol 1999 Jan; 52(1): 47-53

Glucose Tolerance and Serum Lipids

GlucoseTolerance and "Serum" Lipids (Chinese)

This study was designed to investigate the supplemental effects of brewer's yeast on serum glucose and lipids in Chinese adults (8 males and 14 females). Mean "age" of the group was 51 yr, and fasting values of total "cholesterol" and glucose were from 3.21 to 6.90 and 4.3 to 6.2 mmol/L, respectively.

The subjects were randomly assigned into either brewer's yeast or torula yeast group and consumed 10 g yeast powder daily for 12 wk.

Brewer's yeast demonstrated a beneficial effect on decreasing serum triacylglycerol values (p < 0.05).

Brewer's yeast and torula yeast addition significantly altered glucose concentrations at 60.

Likewise, serum "insulin" contents decreased at 90 min after supplementation in the group given torula yeast.

Li-YC: Effects of brewer's yeast on "glucose tolerance" and serum lipids in Chinese adults. Biol-Trace-Elem-Res. 1994 Jun; 41(3): 341-7

Yeast Glucans & Immune Function

Yeast Glucans & Immune Function

Injection of glucans found in yeast may be effective in stimulating immune function within the peritoneal cavity. Researchers injected female mice with varying doses and forms of glucans. The higher MW or (1,6)-linked, (1,3) beta-D-glucans was more stimulatory than other forms. All glucans yielded an increase in neutrophils and eosinophils, while reducing the number of mast cells. Peritoneal macrophages also exhibited morphological changes due to glucan presence, and increased production of NO and intracellular acid phosphatase.

Cleary JA, Kelly GE, Husband AJ: The effect of molecular weight and beta-1,6-linkages on priming of macrophage function in mice by (1,3)-beta-D-glucan, Immunol Cell Biol 1999 Oct;77(5):395-403

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