Abstracts
Diabetes and Coenzyme Q10
Diabetes
We report the case of 71-year-old male who was once diagnosed as having diabetic amyotrophy, because of pronounced wasting in proximal muscles, massive weight loss, and development of paresthesia in his legs.
Coenzyme Q10 administration was effective in relieving the symptoms in his legs, fatigue, and residual urine in his bladder. These were confirmed with the improvement in neurological parameters. In conclusion, this case gives important help in understanding myopathy in diabetes. It would be important to check on the 3243 mitochondrial tRNA mutation in patients with diabetic amyotrophy and/or diabetic neuropathic symptoms.
A case of diabetic amyotrophy associated with 3243 mitochondrial tRNA(leu; UUR) mutation and successful therapy with coenzyme Q10. Suzuki-Y; Kadowaki-H; Atsumi-Y; Hosokawa-K; Katagiri-H; Kadowaki-T; Oka-Y; Uyama-K; Mokubo-A; Asahina-T; et-al. Endocr-J. 1995 Apr; 42(2): 141-5.
Heart & Coenzyme Q10
Heart
The addition of Coenzyme Q10 or of L-carnitine alone results in a higher value of the energy charge and of the adenine nucleotide pool after hypoxia, reperfusion and rotenone inhibition of the respiratory chain, as compared to controls without additions. The protective effect is much stronger when the two compounds are given together.
Conte A et al., Protection of adenylate pool and energy charge by L-carnitine and coenzyme Q10 during energy depletion in rat heart slices. Int J Tissue React, 1990, 12:3, 187-91.
LDL Peroxidation & Coenzyme Q10
LDL Peroxidation
Investigated the relationships between the levels of coenzyme Q10 (CoQ10) and vitamin E and the levels of hydroperoxide in three subfractions of low density lipoproteins (LDL) that were isolated from healthy donors.
LDL3, the densest of the three subfractions, has shown statistically significant lower levels of CoQ10 and vitamin E, which were associated with higher hydroperoxide levels when compared with the lighter counterparts.
After CoQ10 supplementation, all three LDL subfractions had significantly increased CoQ10 levels. In particular, LDL3 showed the highest CoQ10 increase when compared with LDL1 and LDL2 and was associated with a significant decrease in hydroperoxide level. These results support the hypothesis that the CoQ10 endowment in subfractions of LDL affects their oxidizability, and has important implications for the treatment of disease.
The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions. Alleva-R; Tomasetti-M; Battino-M; Curatola-G; Littarru-GP; Folkers-K. Proc-Natl-Acad-Sci-U-S-A. 1995 Sep 26; 92(20): 9388-91.
Parkinson's & Coenzyme Q10
Parkinson's
1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) produces Parkinsonism in both experimental animals and in man. MPTP is metabolized to 1-methyl-4-phenylpridinium, an inhibitor of mitochondrial complex I. MPTP administration produces ATP depletions in vivo, which may lead to secondary excitotoxicity and free radical generation. If this is the case then agents which improve mitochondrial function or free radical scavengers should attenuate MPTP neurotoxicity.
A combination of coenzyme Q10 and nicotinamide protected against both mild and moderate depletion of dopamine.
Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Schulz-JB; Henshaw-DR; Matthews-RT; Beal-MF. Exp-Neurol. 1995 Apr; 132(2): 279-83.
Wrinkles
Wrinkles
Coenzyme Q10 (CoQ10) may significantly reduce the formation of oxidative stress, which plays a significant role in aging. According to in vitro and in vivo experiments, reduced epidermal resistance against oxidative stress may be improved by topical application of CoQ10. Also, wrinkles or crow's feet may be diminished by long term application of CoQ10.
Blatt T, Mundt C, Mummert C, Maksiuk T, Wolber R, Keyhani R, Schreiner V, Hoppe U, Schachtschabel DO, Stab F: Z Gerontol Geriatr 1999 Apr; 32(2): 83-8
Breast Cancer 2
Breast Cancer
Coenzyme Q10 supplementation may be beneficial in treating breast cancer. Coenzyme Q10 (or ubiquinone) is an important component of the respiratory chain, which may be implicated in the pathogenesis of cancer. In a clinical trial, women hospitalized for the biopsy or removal of breast tumor were assessed simultaneously for ubiquinone plasma concentrations and vitamin E plasma concentrations. As a result, 80 patients diagnosed with carcinomas and 120 patients with non-malignant lesions were deficient in coenzyme Q10, but had normal vitamin E levels. Supplementation of coenzyme Q10 may be beneficial in treating breast cancer.
Jolliet P, Simon N, Barre J, Pons JY, Boukef M, Paniel BJ, Tillement JP: Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences, Int J Clin Pharmacol Ther 1998 Sep; 36(9): 506-9
Q-Gel
Q-Gel
In clinical trials, Q-Gel, the new solubilized form of CoQ10, enhances bioavailability as compared to other products of CoQ10. Lower doses of Q- Gel may supply adequate blood CoQ10 values more efficiently than with any other CoQ10 product. Softgel capsules containing CoQ10 suspension in oil, powder-filled hardshell capsules and powder-based tablets and Q-Gel were compared using a daily dosage of 120 mg for three weeks. Approximately, the results showed a 3:1:1:1 ratio among Q-Gel and other CoQ10 products. Lower doses of Q-Gel could be utilized to maintain adequate CoQ10 levels as compared to other products.
Chopra RK, Goldman R, Sinatra ST, Bhagavan HN: Relative bioavailability of coenzyme Q10 formulations in
human subjects, Int J Vitam Nutr Res 1998; 68(2): 109-13
Breast Cancer & Coenzyme Q10
Breast Cancer
In 1993 complete regression of the "tumors" in two cases of breast "cancer" was reported using "CoQ10".
Continuing this research, three additional "breast cancer" patients also underwent a conventional protocol of therapy which included a daily oral dosage of 390 mg of vitamin Q10 (Bio-Quinone of Pharma Nord) during the complete trials over 3-5 years.
The numerous "metastases" in the "liver" of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of "tumor" in the pleural "cavity" after six months, and her condition was excellent.
A 75-year-old patient with "carcinoma" in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases.
Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Lockwood-K; Moesgaard-S; Yamamoto-T; Folkers-K. Biochem-Biophys-Res-Commun. 1995 Jul 6; 212(1): 172-7.
Heart Conditions
Heart Conditions
This study shows that Coenzyme Q10 may lower blood pressure by reducing oxidative stress among patients with hypertension and coronary artery disease (CAD). A trial was performed among patients receiving antihypertensive medication for 8 weeks. Out of 59 patients taking oral medication, 30 received Coenzyme Q10 (60 mg twice daily) and 29 received vitamin B complex. At the end of the trial, among those receiving coenzyme Q10, systolic and diastolic blood pressure, insulin, glucose, and triglycerides were all reduced. Also, HDL cholesterol, vitamins A, C, E and beta-carotene were increased. Among patients taking vitamin B complex, only vitamin C and beta-carotene were increased. Coenzyme Q10 may have a positive effect on those having heart conditions.
Singh RB, Niaz MA, Rastogi SS, Shukla PK, Thakur AS: Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease, J Hum Hypertens 1999 Mar; 13(3):
203-8
Lipoprotein Concentration
Lipoprotein Concentration
Based on a randomized double blind placebo controlled trial, hydrosoluble Coenzyme Q10 (Q-Gel) may decrease lipoprotein concentration among patients with acute coronary disease.
In those patients taking Coenzyme Q10 (60 mg twice daily), serum lipoprotein was reduced by 31% compared to a reduction of 8.2% in the placebo group. CoQ10 also reduced LDL cholesterol, blood glucose and thiobarbituric substances. CoQ10 supplements may be beneficial in treating acute coronary disease.
Singh RB, Niaz MA: Serum concentration of lipoprotein (a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role, Int J Cardiol 1999 Jan; 68(1): 23-9
Liver Transplantation
Liver Transplantation (Rat)
The ability of the benzoquinone Coenzyme Q10 or its derivative QSA-10 (idebenone) to protect against "lipid" peroxidation and "protein" damage mediated by the pro-"oxidative" system NADPH/ADP/Fe3+ was tested in a rat liver microsomal model.
The use of QSA-10 during liver transplantation may therefore have the potential of increasing the efficacy of organ preservation, maintaining donor organ quality, and preventing reperfusion injury. It is suitable for human use and has energy-conserving properties in addition to its "antioxidant" nature.
Idebenone protects "hepatic" microsomes against oxygen radical-mediated damage in organ preservation solutions. Wieland-E; Schutz-E; Armstrong-VW; Kuthe-F; Heller-C; Oellerich-M. Transplantation. 1995 Sep 15; 60(5): 444-51.
Mitochondrial Disease
Mitochondrial Disease
According to this study, Coenzyme Q10 may be beneficial for some patients with mitochondrial diseases. Various metabolic factors involving mitochondrial encephalomyopathies were observed with Coenzyme Q10. All patients observed had pathological venous lactate/pyruvate (L/P) ratios, and in three of the patients the L/P ratio had returned to normal after 6 months of Coenzyme Q10 therapy. Coenzyme Q10 may help patients with mitochondrial diseases.
Chan A, Reichmann H, Kogel A, Beck A, Gold R: Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy, J Neurol 1998 Oct; 245(10): 681-5
Mitochondrial Encephalomyopathy
Mitochondrial Encephalomyopathy
Coenzyme Q10 supplementation may be useful for patients with mitochondrial encephalomyopathy. The effect of Coenzyme Q10 supplementation on two patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes was observed. Both patients showed the impairment in utilizing oxygen during exercise. One patient had severe mitochondrial disorder and another patient's condition was mild. When they received Coenzyme Q10 supplementation, the patient with the severe condition had oxygen consumption levels comparable to the mild form, yet the patient with the mild condition was not affected. Coenzyme Q10 may help patients with severe mitochondrial disorder since the substance had lowered the sum of serum lactate and pyruvate level during exercise.
Abe K, Matsuo Y, Kadekawa J, Inoue S, Yanagihara T: Effect of coenzyme Q10 in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): evaluation by noninvasive tissue oximetry, J Neurol Sci 1999 Jan 1; 162(1): 65-8
Muscle Deficiency
Muscle Deficiency
This report indicates a mitochondrial Coenzyme Q10 muscle deficiency in a patient suffering from an encephalomyopathy. A 4-year old boy who has severe Coenzyme Q10 deficiency showed progressive muscle weakness, seizures, cerebellar syndrome, and a raised cerebro-spinal fluid lactate concentration. The patient's muscle mitochondria with glutamate, pyruvate, palmitoylcarnitine, and succinate as respiratory substrates were deficient. These results determined a mitochondrial Coenzyme Q10 deficiency and that it was tissue-specific. Coenzyme Q10 may be beneficial for those having mitochondrial coenzyme Q10 deficiency.
Boitier E, Degoul F, Desguerre I, Charpentier C, Francois D, Ponsot G, Diry M, Rustin P, Marsac C: A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency, J Neurol Sci 1998; 156(1): 41-6
Muscular Dystrophies
Muscular Dystrophies
Coenzyme Q10 (vitamin Q10) is biosynthesized in the human body and is functional in bioenergetics, anti-"oxidation" reactions, and in growth control, etc. It is indispensable to health and survival.
Definitely improved physical performance was recorded. In retrospect, a dosage of 100 mg was too low although effective and safe. Patients "suffering" from these "muscle" dystrophies and the like, should be treated with vitamin Q10 indefinitely.
Two successful double-blind trials with Coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies. Folkers-K; Simonsen-R. Biochim-Biophys-Acta. 1995 May 24; 1271(1): 281-6.
Warfarin Interaction & Coenzyme Q10
Warfarin Interaction
Coenzyme Q10 may result in a decreased responsiveness to warfarin for those patients taking both the natural supplement and the drug. A 72 year-old female treated with warfarin while taking coenzyme Q10 showed less responsiveness to warfarin. When the patient stopped taking warfarin, her responsiveness normalized. As Coenzyme Q10 is chemically similar to vitamin K, similar interactions with warfarin are suggested. Coenzyme Q10 may decrease the responsiveness of warfarin, when both are taken together.
Landbo C, Almdal TP: Interaction between warfarin and coenzyme Q10, Ugeskr Laeger 1998 May 25; 160(22): 3226-7
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