Abstracts
Anticancer Therapy
Anticancer Therapy
A clinical study has evaluated whether aloe vera may enhance the therapeutic results of pineal indole melatonin (MLT), a neurohormone, for patients with advanced solid tumors. Thus, MLT may activate anticancer immunity. The study included 50 patients suffering from lung cancer, gastrointestinal tract tumors, breast cancer or brain glioblastoma, who were treated with MLT alone or MLT plus A. vera tincture. The percentage of nonprogressing patients was significantly higher in the group treated with MLT plus aloe than in the MLT group. The percent 1-year survival was significantly higher among patients receiving MLT plus aloe. Aloe vera may be a therapeutic agent for cancer patients.
Lissoni P, Giani L, Zerbini S, Trabattoni P, Rovelli F: Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus aloe vera in untreatable advanced solid neoplasms, Nat Immun 1998; 16(1): 27-33
Effects of Aloe Vera
Effects of Aloe Vera
Investigation of the effects of vitamin C and aloe vera gel extract supplementation was found to reduce the severity of induced chemical hepatocarcinogenesis in male Sprague-Dawley rats caused by diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF). Supplementation of vitamin C or aloe vera gel extract to the cancer-induced rats suppressed this increase in DEN and AAF significantly. Hence, aloe vera and vitamin C may reduce the severity of this carcinogen.
Shamaan NA, Kadir KA, Rahmat A, Ngah WZ: Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat, Nutrition 1998 Nov-Dec; 14(11-12): 846-52
Pressure Ulcers (Aloe Vera)
Pressure Ulcers
For centuries, aloe vera has been commonly used as a topical treatment for various conditions and as a cathartic. Thus, this study indicates that the acemannan hydrogel wound dressing, derived from the aloe plant, is as effective as, but is not superior to, a moist saline gauze wound dressing used for pressure ulcers. During this study, complete healing of the ulcer occurred in 19 of 30 subjects (63%) during the trial. No difference was observed in complete healing between the experimental and the control groups.
Thomas DR, Goode PS, LaMaster K, Tennyson T: Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial, Adv Wound Care 1998 Oct; 11(6): 273-6
Treating Wounds
Treating Wounds
These clinical results suggest that aloe vera may influence the wound healing process by enhancing collagen turnover in the wound tissue. Treatment of full-thickness wounds with aloe. vera on rats resulted in increased biosynthesis of collagen and its degradation. Elevated levels of lysyl oxidase also indicated increased crosslinking of newly synthesized collagen. Thus, aloe vera may be beneficial in treating wounds.
Chithra P, Sajithlal GB, Chandrakasan G: Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats, Indian J Exp Biol 1998 Sep; 36(9): 896-901
Wound Healing
Wound Healing
"Aloe vera" at doses of 100 and 300 mg/kg daily for 4 days blocked the "wound" healing suppression of hydrocortisone acetate up to 100% using the wound tensile strength assay. This response was because of the growth factors present in A. vera masking the wound healing inhibitors such as sterols and certain amino acids. The sterols showed good anti-"inflammatory" activity (-36%) in reducing the croton oil-induced "ear" "swelling". This activity displayed a dose-response relationship.
"Aloe" vera, hydrocortisone, and "sterol" influence on wound tensile strength and anti-"inflammation". Davis-RH; DiDonato-JJ; Johnson-RW; Stewart-CB. J-Am-Podiatr-Med-Assoc. 1994 Dec; 84(12): 614-21.
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