Abstracts
Neonates & Caprylic Acid
Neonates
In premature neonates a significant increase of caprylic acid and arachidonic acid in the blood-serum was detected. The significance of described changes in the participation of single fatty acids in the premature neonates for their maturation, structural evolution especially of the brain cells and for therapy, is discussed.
[Serum fatty acids in premature neonates] Vizek-K; Mourek-J; Base-J; Smidova-L; Mikova-M; Cechova-I. Sb-Lek. 1993; 94(1): 19-24.
The outcome after major bowel resection in the neonatal "period" depends primarily on the time needed for bowel adaptation. A prospective study was begun in neonates after small bowel resection to evaluate the absorptive capacity of the bowel and growth parameters as a result of adaptation of the bowel.
The coefficient of absorption of the different "fatty acids" showed complete absorption of caprylic acid.
Prospective evaluation of the absorptive capacity of the bowel after major and minor resections in the neonate. Liefaard-G; Heineman-E; Molenaar-JC; Tibboel-D. J-Pediatr-Surg. 1995 Mar; 30(3): 388-91
Breath Test
Breath Test
The recently developed 13C-octanoic acid breath test allows the measurement of gastric emptying of solids. Investigated whether the 13C-octanoic acid breath test using breath samples every half an hour is suitable in assessing gastric emptying in comparison to scintigraphy in diabetics.
For detailed assessment of solid gastric emptying in diabetics a 13C-octanoic acid breath test using shorter breath sampling intervals is recommended.
[Non-invasive 13C octanoic acid breath test for measuring "stomach" emptying of a solid test meal--correlation with scintigraphy in "diabetic" patients and reproducibility in healthy probands] Pfaffenbach-B; Wegener-M; Adamek-RJ; Wissuwa-H; Schaffstein-J; Aygen-S; Hennemann-O. Z-Gastroenterol. 1995 Mar; 33(3): 141-5.
Gastric Emptying & Caprylic Acid
Gastric Emptying
The effects of octreotide on small intestinal and gall-"bladder" motility are well established. However, the influence of octreotide on the gastric emptying rate of both solids and liquids in normal healthy volunteers has never been studied.
The gastric emptying rate of liquids and solids was studied in basal condition and 30 min after subcutaneous administration of 50 micrograms of octreotide, using the combined 14C-octanoic acid/13C-"glycine" breath test.
Subcutaneous injection of a single physiological dose of octreotide induces a marked delay in the gastric emptying of solids and liquids in young healthy volunteers. The combined 14C-octanoic acid/13C-glycine breath test is very well suited to demonstrate this effect, since the absorption and "metabolism" of octanoic acid and glycine remains unaltered after administration of octreotide.
Influence of octreotide on the gastric emptying of solids and liquids in normal healthy subjects. Maes-BD; Ghoos-YF; Geypens-BJ; Hiele-MI; Rutgeerts-PJ. Aliment-Pharmacol-Ther. 1995 Feb; 9(1): 11-8.
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