Abstracts
Breath (Sulfonylmethane)
Breath
A set of three complementary analytical methods were developed specifically for exhaled breath as collected in evacuated stainless steel canisters using gas chromatographic-mass spectrometric detection.
The first is a screening method to quantify the carbon dioxide component (generally at 4-5% concentration), the second method measures the very volatile high-level endogenous compounds [e.g. acetone and isoprene at 500-1000 parts per billion by volume (ppbv), methanol, ethanol, dimethylsulfide at 2-10 ppbv], and the third method is designed to measure trace-level environmental contaminants and other endogenous volatile organic compounds (VOCs) (sub-ppbv) in breath.
Example chromatograms and quantitative data plots demonstrating the utility of the methods are presented.
Pleil JD & Lindstrom AB : Measurement of volatile organic compounds in exhaled breath as collected in evacuated electropolished canisters. J Chromatogr B Biomed Appl, 1995 Mar 24, 665:2, 271-9.
Anthelmintic Properties
Anthelmintic properties
A new synthesized form of disulfonylmethane compounds may have anthelmintic and insecticidal properties, according to these researchers. The compounds have been shown to act against the internal nematode Haemonchus contortus, with a 100% control rate at 10mg/kg. Respiratory control index values on rat liver mitochondria for this series suggested uncoupling of oxidative phosphorylation as a mechanism of action. The researchers consider compound 1 to be a promising agent for treatment of parasitized sheep.
Wickiser DI, Wilson SA, Snyder DE, Dahnke KR, Smith CK 2nd, McDermott PJ: Synthesis and endectocidal activity of novel 1-(arylsulfonyl)-1-[(trifluoromethyl)sulfonyl]methane derivatives, J Med Chem 1998 Mar 26;41(7):1092-8
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