Diabetic Medications
Acarbose (Precose)
Chlorpropamide (Diabenese)
Glimepiride (Amaryl)
Glipizide (Glucotrol)
Glyburide (Diabeta, Micronase)
Metformin (Glucophage)
Miglitol (Glyset)
Repaglinide (Prandin)
Rosiglitazone (Avandia)
Tolbutamide (Orinase)
Tolazamide (Tolinase)
Nutritional Considerations:
Limit alcohol. (Threlkeld 1992)
Do not take ipriflavone with oral hypoglycemics without consulting your pharmacist. It may raise levels of the drugs. (Monostory 1998)
Metformin may cause Vitamin B12 deficiency. With long-term use of the drug, ask your pharmacist if supplementation may be beneficial. (Adams 1983) (Facts and Comparisons 2000)
The digestive enzymes amylase and pancreatin decrease the effects of Miglitol and acarbose. (Facts and Comparisons 2000)
Prolonged use of miglitol and acarbose may decrease blood iron levels, due to decreased absorption of iron. (Facts and Comparisons 2000) (Pronsky 1999)
Chlorpropamide, and tolazamide may cause reduction in co-enzyme Q10. Ask your pharmacist whether supplementation may be beneficial. (Kishi 1976)
Because magnesium can increase the absorption of chlorpropamide, do not take magnesium supplements with this drug. (Pronsky 1997)
Take glipizide on an empty stomach, food delays absorption by up to 40 minutes. (Facts and Comparisons 2000)
Caution with high doses of nicotinic acid because it raises glucose levels. (Balch 1997) (Pronsky 1999).
Vitamin E enhances insulin activity and should, therefore, be avoided while taking antidiabetic medications. (Paolisso 1993)
Avoid co-enzyme Q10 and grapefruit juice with repaglinide (prandin), they may increase the effects of the drug. (Ho PC 2000) (Kishi 1976) (Singh 1999)
Avoid L-carnitine and chromium with oral antidiabetic agents because there could be an additive glucose-lowering effect. (Anderson 1997) (Mingrone 1999) (Singh 1999)
Herbal Considerations:
Avoid the following herbs with the above drugs, they may increase the effects of antidiabetic medications: Alfalfa, Aloes, Bilberry, Bitter melon, Blueberry, Burdock, Celery, Cornsilk, Dandelion, Eucalyptus, Fenugreek, Garlic, Ginger, Ginseng, Juniper, Nettle, Onion, Pterocarpus, and Salt bush (Brinker 1998) (Manickam M 1997)
References
Adams JF, Clark JS, Ireland JT, et al: Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy, Diabetologia, 1983, 24(1):16-8.
Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr. 1997 Oct;16(5):404-10.
Balch JF, Balch PA: Prescription for Nutritional Healing, 1997, p. 231.
Brinker F. Herb contraindications and drug interactions, 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998: 36, 71, 75, 77, 82.
Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
Ho PC, Saville DJ, Coville PF, Wanwimolruk S. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm Acta Helv. 2000 Apr;74(4):379-85.
Kishi T, Kishi H, Watanabe T, et al: Bioenergetics in clinical medicine - studies on coenzyme Q and diabetes mellitus, J Med, 1976, 7(3-4):307-21.
Manickam M, Ramanathan M, Jahromi MA, et al. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod 60: 609-610, 1997.
Mingrone G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Col Nutr 18: 77-82, 1999.
Monostory D, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol.123(4): 605-610, 1998.
Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993.
PDR (Physicians Desk Reference). 49th Edition. Medical Economics Co. Montvale, NJ. 1995.
Pronsky Z, ed. Power's and Moore's food and medication interactions, 10th ed. Pottstown, PA: Food-Medication Interactions, 1997: 60.
Pronsky, Z Food Medication Interaction, 11th edition, 1999
Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Human Hypertens 13: 203-208, 1999.
Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992.
| Signup Free Applied Health Journal |
||||
|
FREE Sample Issue Your email address is all we need to start you on a better path to health. We respect your privacy.
|
