Antibiotics
Aminoglycosides
Neomycin (Neomycin, Audicort, Polybactrin, Tribiotic, Cicatrin)
Streptomycin (Streptomycin)
Tobramycin (Nebcin)
Cephalosporins
Cefaclor (Ceclor)
Cephalexin (Keflex)
Fluoroquinolones
Ciprofloxin (Cipro)
Levofloxacin (Levaquin)
Ofloxacin (Floxin)
Lincosamides
Clindamycin (Cleocin)
Macrolides
Azithromycin (Zithromax)
Clarithromycin (Biaxin)
Erythromycin (E-Mycin, Ilosone, PCE)
Penicillins
Amoxicillin (Amoxil, Trimox)
Amoxicillin/Clavulanate (Augmentin)
Sulfonamide Antibiotics
Sulfadiazine (Sulfadiazine)
Sulfamethizole (Thiosulfil Forte)
Sulfisoxazole (Sulfisoxazole)
Sulfamethoxazole (Gantanol)
Trimethoprim/Sulfamethoxazole (Bactrim, Cotrim, Septra)
Tetracyclines
Demeclocycline HCl (Declomycin)
Doxycyline (Periostat, Vibramycin)
Minocycline (Dynacin, Minocin)
Oxytetracycline (Terramycin)
Tetracycline HCl (Sumycin)
Nutritional Considerations:
Drink plenty of fluids, unless otherwise directed. (Facts and Comparisons 2000) (Pronsky 1999)
Avoid alcohol. (Pronsky 1999)
Prolonged antibiotic use can kill normal intestinal bacteria, and may cause bacterial or fungal overgrowth, called superinfections. To offset this loss of friendly bacteria supplementation with acidophilus and bifidus may be beneficial. Ask your pharmacist. (Bengmark 1996), (Cummings 1997) (Facts and Comparisons 2000) (Fuller 1991)
Antacids, calcium, zinc and iron salts may interfere with the absorption of some antibiotics, separate their use by at least 2 hours. (Cardona 1999)(Facts and Comparisons 2000)
Bromelain may increase absorption of antibiotics. (Brinker 1998) (Neuvonen 1977) (Tinozzi 1978)
Use of trimethoprim/sulfamethoxazole may increase serum potassium levels (Alappan 1996). This can be dangerous if a potassium supplement or other potassium retaining medications are also being used.
Take tetracyclines one hour before or two hours after food or milk. (Facts and Comparisons 2000)
Herbal Considerations:
Safrole (in sassafras) may increase the liver toxicity of several drugs, including antibiotics, antifungal and antituberculous drugs. Avoid when taking antibiotics. (Brinker 1998)
Ginger may cause malabsorption. Consult your pharmacist before taking large quantities of ginger with antibiotics. (Brinker 1998)
Siberian Ginseng may increase the action of antibiotics. Consult your pharmacist before taking this herb with antibiotics. (Brinker 1998)
There may be an increased risk of bleeding in some people in combining celery, clove, fenugreek, feverfew, garlic, ginkgo, ginseng (Panax), licorice, meadowsweet, prickly ash, and willow with cephalosporins, fluoroquinolones, macrolides, penicillins, sulfonamides, and tetracyclines. Consult your pharmacist before using these herbs with the above-mentioned antibiotics. (Blumenthal 1998) (Brinker 1998) (Newall 1996)
St. John's Wort increases sun sensitivity caused by sulfa drugs. (Brockmoller 1997) (Seigers 1993)
References:
Alappan R, Perazella MA, Buller GK. Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole. Ann Intern Med 1996;124:316-20.
Bengmark S & Gianotti L: Nutritional support to prevent and treat multiple organ failure. World J Surg, 1996 May, 20:4, 474-81.
Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
Brinker, F. Herb Contraindications and Drug Interactions. Eclectic Institute, 1998.
Brockmoller J, et al. Hypericin and pseudohypericin: Pharmacokinetics and effects of photosensitivity in humans. Pharmacopychiatry (suppl. 2): 94 - 101, 1997.
Cardona Pera D. Drug-food interactions. Nutr Hosp. 1999 May;14 Suppl 2:129S-140S. Spanish.
Cummings JH, Macfarlane G: Role of intestinal bacteria in nutrient metabolism, JPEN J Parenter Enteral Nutr, 1997, 21(6): 357-65
Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
Fuller R. Probiotics in human medicine. Gut 32: 439-442, 1991
Neuvonen PJ et al., Comparative effect of food on absorption of ampicillin and pivampicillin. J Int Med Res 1977; 5: 71-76.
Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
Pronsky, Zaneta. Food Medication Interactions. 11th edition. 1999.
Seigers Cp, et al. Phototoxicity caused by hypericum. Nervehielkunde 12: 320 - 322, 1993.
Tinozzi S, Venegoni A. Effect of bromelain on serum and tissue levels of amoxicillin. Drugs Exp Clin Res 1978;4:39-44.