Abstracts
Anti-inflammatory 1
Anti-inflammatory (1)
This family includes Boswellia as well as guggul.
Comparisons were made with a rat paw model against established pharmaceuticals (Indomethacin and Prednisolone).
Certain triterpines were isolated. Results were promising.
Duwieja, M et al., Anti-inflammatory activity of resins from some species of the plant family Burseraceae. Planta Med. 1993, 59(1):12-16.
Anti-inflammatory 2
Anti-inflammatory (2)
Commiphora mukul 500 mg/kg was used and proved to decrease the thickness of joint swelling as did phenylbutazone and ibuprofen.
Sharma, JN & Sharma, JN: Comparison of anti-inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. Arzn Forsch. 1977, 27(7):1,455-1,457.
Hypolipidemic & Antioxidant Effects
Hypolipidemic & Antioxidant Effects
Guggulipid (50 mg b.i.d.) was compared with placebo for 24 weeks.
A fruit and vegetable-enriched prudent diet was also followed.
Total "cholesterol", LDL cholesterol and "triglyceride" levels fell by c. 12%. HDL remained unchanged.
The combined effect of diet and guggulipid was equivalent to that of modern drugs.
Singh, RB et al., Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemias. Cardiovasc. Drugs Ther. 1994, 8(4):659-664.
Hypolipidemic Activity 1
Hypolipidemic Activity (1) (Animal study)
Most interestingly, a mixture of "garlic" and guggulu was most effective.
A powder form was used at a dosage of 4.25 mg/kg.
Dixit, VP et al., Hypolipidemic activity of guggul "resin" (Commiphora mukul) and "garlic" (Alium sativum linn.) in dogs (Canis familiaris) and monkeys (Presbytis entellus entellus Dufresne). Biochem. Exp. Biol. 1980, 16(4):421-424.
Hypolipidemic Activity 2
Hypolipidemic activity (2) (Animal study)
All 3 agents were found to confer significant protection against atherogenic diet induced "atherosclerosis".
Lata, S et al., Beneficial effects of "Allium sativum", "Allium cepa" and Commiphora mukul on experimental "hyperlipidemia" and atherosclerosis - a comparative evaluation. J. Postgrad. Med. 1991, 37(3):132-135.
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