Abstracts
Antimutagenic & Anticarcinogenic Action
Antimutagenic and anticarcinogenic action
Resveratrol, a phenolic compound found at high levels in wine, may have strong antimutagenic and anticarcinogenic effects on cells, according to this study performed on various animal and human cell lines. Resveratrol inhibited cell growth by 50% when applied in concentrations of 20 to 100 microM. It was also found that the compound significantly reduced the number of cells in the growth phase of the cell cycle and increased the number of cells in the stationary phase.
Not only did resveratrol exhibit anticarcinogenic properties, but it displayed antimutagenic protection as well. When cells were exposed to oxidative agents, resveratrol prevented the increase in reactive oxygen species that usually occurs. The compound also displayed an ability to reduce nuclear DNA fragementation.
Sgambato A, et al: Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage, Mutat Res 2001 Sep 20;496(1-2):171-80
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